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Intramyocellular lipids (IML)
mccoy posted a topic in General Health and LongevityThe LAtest podcast from Peter Attia with Gerald Schulman. Among other very interesting pieces of info, one I noticed in particular: Schulman studies the flux of glucose in the body tissues, and observed by NMR that intramyocellular lipids (IML), fats inside cell tissues, are responsible for insulin resistance: diminished uptake capacity of glucose in muscle cells (also liver cells if I remember well). We've briefly discussed in this forum the IML theory, supported by the vegan cardiologist Neil Barnard and other low-fat vegan doctors. At the time Michael Rae discarded this theory as not too useful, but now the evidence Schulman has produced seems indisputable. In other words, even as too many carbs may cause T2D, too many fats in some people, if absorbed into cells, may cause T2D because of glucose transport blockage due to IML. The hypothesis from Denise Minger, also discussed in this forum, according to which the extremes (low-carb hi-fat and hi-carbs low fat) may both be beneficial to T2D, seems to have a strong empirical support now.