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Dear colleagues, This Spring, as always, there was the annual Conference on Aging at UR. The keynote speaker was Matt Kaeberlein, of the University of Washington. I was particularly interested in attending his talk -- Prof. Kaeberlein spoke at one of the previous CR Society Conferences that I had attended. Matt's talk both surprised and interested me. Matt did not discuss Calorie Restriction -- but he did discuss studies involving the use of rapomycin as an anti-aging drug. He made the point that the side-effects of rapomycin that have been identified are minor (rapomycin is often used as a drug with transplant patients to reduce the likelihood of organ rejection, due to a lowering of the immune response). Dr. Kaeberlein pointed out that studies had not been done on healthy humans; he clearly would support that, but of course the FDA would not approve of such a study without extensive animal studies first. As we know, studies on fruit flies and rodents have shown both (average) lifespan and (possibly more important) healthspan increases. Dr. Kaeberlein has received approval for a study on large pet dogs. (Small dogs live on average much longer than large dogs, which have comparatively short lifespans.) Owners of large pet dogs can voluntarily enter the study -- some dogs will receive rapomycin, some a placebo. Since pet dogs are cared for by their owners, the cost of the study is greatly reduced from what a comparable study might cost if the dogs were in cages on site. After the talk, I asked Dr. Kaeberlein if he believed that CRON and taking rapomycin might work together synergystically. He told me that there were overlaps in the effects of both anti-aging procedures, but they were not identical. As to whether they would work well together, he answered truthfully that he had no idea -- he said that it would be impossible to get grant money to support such a study. I asked Dr. Kaeberlein if he still was on CR. He isn't; he said that he never had been. He "likes his food". 😋 -- Saul
[Admin Note: Observer (the OP) and others - I apologize for moving this post around. After (nearly) completing a long response, I realize just how interesting Observer's questions are, and how they deserve their own thread in the CR Practice Forum. Thanks Observer! I'll be posting a detailed response shortly. - Dean] Great, now you guys somewhat discouraged me in throughout this thread. Just when I was getting a little bit more serious about starting a proper CR regime, after ~10 years of hesitation. But now you convinced me CR probably doesn't do much for us humans, compared to just eating/exercising healthy and staying slim. I am currently on some mild-CR plan with one 24-hour fast every week and my BMI is 21.5. Was planning on lowering it down do 19-20, but now I don't see a reason for doing it anymore. :( Before I believed I would gain at least 5-8 additional years, especially because of my own anecdotal evidence. I am somewhat a unique human specieman in that I was basically on CR for most of my life, unknowingly.. I simply rejected food, never liked sweets and was always semi-anorexic. As a result (I guess) I was developing slower as a child and always looked much younger than my peers. Even now in my late 30's people think I look 25-30 and I do agree my biological age must be closer to 30. Then again, what do I know? Now reading your posts Dean, you seem like a reasonable individual and you convinced me that we probably cannot gain more than ~2 years through CR and possibly even shorten our lifespan.. So the obvious question is, why do you - and others - even continue practicing it? Why not simply live healthy lives? I'm thinking perhaps I should only concentrate on fasting and autophagy that comes with it? What are your thoughts on that Dean, if you don't mind answering?