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  1. Maria Grazia

    CR for women

    Hi ? I'm new here. I'm a 20 years old girl from Italy (forgive my eventual english mistakes, please), psychology undergraduate. I'm interested in CR for its immediate health benefits and the promise of aging well more than for increasing lifespan (and since my budget is not infinite I like the fact that buying less food would allow me to invest on quality). I would like to understand if and how it could be compatible with an optimal reproductive health, since I'm young and the goal here is to feel better, not worse, and since from what I understand women's hormones balance is more vulnerable to caloric restriction and fat loss. I'm on the high end of the healthy range of BMI (24.1) but I have a high waist to hip ratio for my age (0.78) that I would like to reduce so I'm pretty sure I could benefit from a patient, balanced, weight loss diet, but the question is: as a young woman how far should I go for optimal health (immediate physical health + hormonal balance, meaning reproductive and mental health + aging well)? Should I do a common diet limited in time and then raise my calories for hormonal balance hoping to mantain eating clean as much as my budget allows or prefer a slight chronic caloric restriction that would allow me to buy and eat only high quality food (with the exception of social occasions)?
  2. [Note: another one for the elusive "Non-CR Health & Longevity" Forum...] All, Here are highlights from an interesting new study [1] investigating the link between the activity of certain neurons in your hypothalamus (which are known to be involved in feeding and compulsive behavior) and bone health. To quote the authors: "The less hungry you are, the lower your bone density, and surprisingly, the effects of these neurons on bone mass are independent of the effect of the hormone leptin on these same cells." I'm rarely hungry, but maybe hunger is good for us after all! --Dean ---------------- [1] AgRP Neurons Regulate Bone Mass Jae Geun Kim, Ben-Hua Sun, Marcelo O. Dietrich, Marco Koch, Gang-Qing Yao, Sabrina Diano, Karl Insogna6, Tamas L. Horvath DOI: http://dx.doi.org/10.1016/j.celrep.2015.08.070 The hypothalamus has been implicated in skeletal metabolism. Whether hunger-promoting neurons of the arcuate nucleus impact the bone is not known. We generated multiple lines of mice to affect AgRP neuronal circuit integrity. We found that mice with Ucp2 gene deletion, in which AgRP neuronal function was impaired, were osteopenic. This phenotype was rescued by cell-selective reactivation of Ucp2 in AgRP neurons. When the AgRP circuitry was impaired by early postnatal deletion of AgRP neurons or by cell autonomous deletion of Sirt1 (AgRP-Sirt1−/−), mice also developed reduced bone mass. No impact of leptin receptor deletion in AgRP neurons was found on bone homeostasis. Suppression of sympathetic tone in AgRP-Sirt1−/− mice reversed osteopenia in transgenic animals. Taken together, these observations establish a significant regulatory role for AgRP neurons in skeletal bone metabolism independent of leptin action.