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  1. Premise: as we all know, low mTOR activity (but not too low) has been correlated to longevity. This discussion on trying to find a rationale to downregulate mTOR, hence living longer, by adopting a specific dietary regime. Rapamycine downregulates mTOR regardless of dietary regime, but has the pretty serious drawback that it tends to downregulate it too much, possibly inhibiting the activity of macrophages hence weakening the immune system. Plus more undesired effects (hyperglycaemia, testiculat atrophy, cataratc...). In the other thread in this same section on nutritional geometry, one of the articles cited is the following. There, I saw something which I didn't see anywhere else: the mapping of hepatic mTOR activity, in function of the macronutrients levels. Even though that's in lab rats, after so many theoretical considerations it's awesome to see the real deal. Cell Metab. 2014 Mar 4;19(3):418-30. doi: 10.1016/j.cmet.2014.02.009. The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice. Solon-Biet SM1, McMahon AC2, Ballard JW3, Ruohonen K4, Wu LE5, Cogger VC2, Warren A2, Huang X2, Pichaud N3, Melvin RG6, Gokarn R7, Khalil M8, Turner N9, Cooney GJ9, Sinclair DA10, Raubenheimer D11, Le Couteur DG12, Simpson SJ13.