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Promising research on health/lifespan benefits via NAD+ enhancement
ras posted a topic in CR Science & Theory
The latest issue of Nature reports that "Genetic and pharmacological inhibition of ACMSD boosts de novo NAD+ synthesis and sirtuin 1 activity, ultimately enhancing mitochondrial function." The abstract is available here for non-subscribers. A related complete article by the lead author of the Nature report is available here for download. According to its abstract: "Altered NAD + metabolism is associated with aging and many pathological conditions, such as metabolic diseases and disorders of the muscular and neuronal systems. Conversely, increased NAD + levels have shown to be beneficial in a broad spectrum of diseases. Here, we review the fundamental aspects of NAD + biochemistry and metabolism and discuss how boosting NAD + content can help ameliorate mitochondrial homeostasis and as such improve healthspan and lifespan." -
I've just read "Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)" [1], and am starting to worry about all the supplements many of us take. I'd love to get others' views on this topic. Myself, I'd like to be as supplement-free as possible, but, obviously, many supplements wouldn't likely interfere with hormesis in a deleterious way. It would be great if there were a way to measure the effect of supplements on mtDNA function -- well, there are ways, but I mean: a way that's not hugely expensive and is accessible to the average CR'er. Brian [1] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036400/
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