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I've just read "Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)" , and am starting to worry about all the supplements many of us take. I'd love to get others' views on this topic. Myself, I'd like to be as supplement-free as possible, but, obviously, many supplements wouldn't likely interfere with hormesis in a deleterious way. It would be great if there were a way to measure the effect of supplements on mtDNA function -- well, there are ways, but I mean: a way that's not hugely expensive and is accessible to the average CR'er. Brian  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036400/