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This is one of the latest citations from Al Pater's thread: It's interesting to observe that, in men with mean/Sd age 73/5.8, even with the administration of testosterone (which boosts IGF-1 concentration), an increase from the 0.8 g/kg/d to 1.3 g/kg/d did not have effect on LBM and strenght. Obviously, that's because of the lack of physical exercise. An interpretation of the study from the POW of cellular signaling may be that, even in the presence of the amminoacid+IGF-1 signal, the contribute of the mechanoreceptors signal (physical stress) is absolutely essential to obtain an upregulation of mTOR in skeletal muscle, at least in those aged 70+.