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  1. https://www.youtube.com/watch?v=9nuoKbMNCbo&lc=Ugz6FWkNk7mMWATxO9x4AaABAg Papers referenced in the video: Sirtuins, Healthspan, and Longevity in Mammals https://www.sciencedirect.com/science... Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH https://pubmed.ncbi.nlm.nih.gov/24011... Resveratrol improves health and survival of mice on a high-calorie diet https://pubmed.ncbi.nlm.nih.gov/17086... Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice https://pubmed.ncbi.nlm.nih.gov/20974... Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer https://www.nature.com/articles/ncomm... Restoration of energy homeostasis by SIRT6 extends healthy lifespan https://pubmed.ncbi.nlm.nih.gov/34050... The sirtuin SIRT6 regulates lifespan in male mice https://pubmed.ncbi.nlm.nih.gov/22367... SIRT6 in Senescence and Aging-Related Cardiovascular Diseases https://pubmed.ncbi.nlm.nih.gov/33855... Calorie restriction-induced SIRT6 activation delays aging by suppressing NF-κB signaling https://pubmed.ncbi.nlm.nih.gov/26940... Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6 https://pubmed.ncbi.nlm.nih.gov/27101... A Comprehensive Analysis into the Therapeutic Application of Natural Products as SIRT6 Modulators in Alzheimer’s Disease, Aging, Cancer, Inflammation, and Diabetes https://pubmed.ncbi.nlm.nih.gov/33920... Acute Exercise Leads to Regulation of Telomere Associated Genes and MicroR A Expression in Immune Cells https://pubmed.ncbi.nlm.nih.gov/24752... The effect of 12-week resistance exercise training on serum levels of cellular aging process parameters in elderly men https://pubmed.ncbi.nlm.nih.gov/32919...
  2. I posted about this a while back on the (now defunct) CR email list, but I thought it interesting enough to bring up here, especially since the forum enables the inclusion of a very nice graphic illustration (see below)... CR (and exercise) are thought to serve as stressors which actively upregulate endogenous repair and defensive mechanisms that improve health and longevity in insects and animals. But plants have also had billions of years to evolve similar endogenous mechanisms to protect themselves from environmental stresses like drought, famine, insects, diseases, etc. The idea of xenohormesis is that phytochemicals are the signalling mechanisms of these stress responses in plants, and they are healthy for us because we share many of the same biochemical pathways with plants. The way Dr. Greger puts it in this video, rather than endure the hardship (sic?!) of calorie restriction ourselves to upregulate our defenses, why not torture plants, then eat them to gain the benefits of CR via the CR memetics they produce in response to the stress. What I thought was most interesting in the video was this figure (click to enlarge): which shows how specific, well-known plant phytonutrients (Curcumin in turmeric/curry powder, Resveratrol in red wine and ECGC in green tea), influence the same pathways that are modulated by calorie restriction (i.e. "low energy" in the diagram), and therefore may serve as (partial) CR mimetics. For more discussion on the topic, see this thread from the old mailing list. --Dean