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Hi CR Society Friends! For my first post here, I'd like to ask our community if anyone has come across published research similar to that which is currently being discussed in the "Fasting for CR Benefits?" topic in this forum. That topic, which I highly recommend, is discussing the University of Wisconsin-Madison study on fasting driving the positive effects of a CR diet in mice. So as to not sidetrack that topic, anyone familiar with studies that, for example, have compared time restricted feeding (TRF) windows (16:8 versus 18:6?), particularly in relation to CR, is more than welcome to discuss them here. One study (Sutton et al., 2018) randomized men with prediabetes into an early TRF (6 hour feeding period, with dinner before 3 p.m.) or a control schedule (12 hour feeding period) and later crossed the groups over to the other schedule. The early TRF significantly improved some aspects of cardiometabolic health (even without any weight loss). My criticism of that study is that there were two (potentially confounding) variables (early versus later eating as well as a 6 versus 12 hour feeding window) that differed in the experimental and control groups. The study begs for a follow-up (which I haven't found) comparing only early versus late TRF. Nonetheless, the results are noteworthy. I'd very much appreciate reading anyone's thoughts or knowledge on such topics. Thanks!
Dean Pomerleau posted a topic in General Health and LongevityAll, I personally don't do extended fasts except on rare occasions (like my last colonoscopy, when I had to go 5 days without food to clear out my colon for imaging). But I do eat in a limited time window, and fast for most of the day and night, both for convenience, and because I believe it to be healthy for a number of reasons (reduced glucose / insulin exposure, increased autophagy, etc). It looks like we can add 'reducing breast cancer recurrence' to the list of benefits of an extended overnight fast, according to a new study  in this month's issue of JAMA (popular press story). In a study of 2400 breast cancer survivors, researchers found that waiting more than 13 hours between her last meal or snack in the evening and her first meal in the morning resulted in a 36% reduction in a woman's risk of breast cancer recurrence relative to fasting for less than 13 hours. The women who fasted longer had better markers of glucose control (HbA1C) and increased sleep duration. The researchers think these benefits may have been at least partly responsible for the reduction in breast cancer recurrence. --Dean ------------  JAMA Oncol. 2016 Mar 31. doi: 10.1001/jamaoncol.2016.0164. [Epub ahead of print] Prolonged Nightly Fasting and Breast Cancer Prognosis. Marinac CR(1), Nelson SH(2), Breen CI(3), Hartman SJ(4), Natarajan L(4), Pierce JP(4), Flatt SW(3), Sears DD(5), Patterson RE(4). Free full text: http://oncology.jamanetwork.com/article.aspx?articleid=2506710 Importance: Rodent studies demonstrate that prolonged fasting during the sleep phase positively influences carcinogenesis and metabolic processes that are putatively associated with risk and prognosis of breast cancer. To our knowledge, no studies in humans have examined nightly fasting duration and cancer outcomes. Objective: To investigate whether duration of nightly fasting predicted recurrence and mortality among women with early-stage breast cancer and, if so, whether it was associated with risk factors for poor outcomes, including glucoregulation (hemoglobin A1c), chronic inflammation (C-reactive protein), obesity, and sleep. Design, Setting, and Participants: Data were collected from 2413 women with breast cancer but without diabetes mellitus who were aged 27 to 70 years at diagnosis and participated in the prospective Women's Healthy Eating and Living study between March 1, 1995, and May 3, 2007. Data analysis was conducted from May 18 to October 5, 2015. Exposures: Nightly fasting duration was estimated from 24-hour dietary recalls collected at baseline, year 1, and year 4. Main Outcomes and Measures: Clinical outcomes were invasive breast cancer recurrence and new primary breast tumors during a mean of 7.3 years of study follow-up as well as death from breast cancer or any cause during a mean of 11.4 years of surveillance. Baseline sleep duration was self-reported, and archived blood samples were used to assess concentrations of hemoglobin A1c and C-reactive protein. Results: The cohort of 2413 women (mean [sD] age, 52.4 [8.9] years) reported a mean (SD) fasting duration of 12.5 (1.7) hours per night. In repeated-measures Cox proportional hazards regression models, fasting less than 13 hours per night (lower 2 tertiles of nightly fasting distribution) was associated with an increase in the risk of breast cancer recurrence compared with fasting 13 or more hours per night (hazard ratio, 1.36; 95% CI, 1.05-1.76). Nightly fasting less than 13 hours was not associated with a statistically significant higher risk of breast cancer mortality (hazard ratio, 1.21; 95% CI, 0.91-1.60) or a statistically significant higher risk of all-cause mortality (hazard ratio, 1.22; 95% CI, 0.95-1.56). In multivariable linear regression models, each 2-hour increase in the nightly fasting duration was associated with significantly lower hemoglobin A1c levels (β = -0.37; 95% CI, -0.72 to -0.01) and a longer duration of nighttime sleep (β = 0.20; 95% CI, 0.14-0.26). Conclusions and Relevance: Prolonging the length of the nightly fasting interval may be a simple, nonpharmacologic strategy for reducing the risk of breast cancer recurrence. Improvements in glucoregulation and sleep may be mechanisms linking nightly fasting with breast cancer prognosis. PMID: 27032109