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CRON is well known to greatly reduce inflammation. For years, I've been measuring CRP and TNF_alpha, which are supposed to be measurements of inflammation. All but once, I've gotten CRP <5, meaning immeasurably low. All but the last two measurements (in 2016 and 2017) were vanishingly small for TNF_alpha as well -- but the last two measurements were surprisingly high. So a major contradiction between CRP (vanishingly small) and TNF_alpha (high) on these last two measurements. Weird. I asked my CR friendly nephrologist. He didn't know; suggested that I check with some of the CRONNies -- I guess he thinks it possible that it might be one of the weird looking numbers that happen with CR. So I'm following his advice. Anybody -- who is knowledgeable in the mechanisms of these proteins -- have any ideas? -- Saul