arwin77 Posted February 20, 2015 Report Share Posted February 20, 2015 I'm wondering if anyone has thoughts about the appropriate upper limit for diurnal (morning) serum cortisol in CR. I know it's supposed to be high, but I'm having trouble finding appropriate benchmarks. My concern is -- how high? And are there corresponding biomarkers that one might correlate with cortisol being too high such as glucose? I seem to only find salivary. Also, if anyone has any conversion (salivary --> serum) that might be helpful. Thanks very much! Link to comment Share on other sites More sharing options...
Michael R Posted February 20, 2015 Report Share Posted February 20, 2015 Hi there (are you the same Prophets as on Longecity?), I wish there were data from the WUSTL study in our cohort. The best I can find is from the Biosphere natural experiment: It looks like total cortisol climbed from 15 to 19 µg/dL during their period in the Biosphere, while cortisol binding globulin rose in response in the range of 3.1 to 3.3 mg/dL (someone could perhaps contribute a molar ratio conversion), keeping free cortisol hovering pretty narrowly at 2.0-2.1 µg/dL.(1) Reference 1: Walford RL, Mock D, Verdery R, MacCallum T. Calorie restriction in biosphere 2: alterations in physiologic, hematologic, hormonal, and biochemical parameters in humans restricted for a 2-year period. J Gerontol A Biol Sci Med Sci. 2002 Jun;57(6):B211-24. PubMed PMID: 12023257. Link to comment Share on other sites More sharing options...
arwin77 Posted February 21, 2015 Author Report Share Posted February 21, 2015 Hi there (are you the same Prophets as on Longecity?), Yes. Thanks for such a comprehensive response. I appreciate it. Link to comment Share on other sites More sharing options...
Guest Guest Posted February 21, 2015 Report Share Posted February 21, 2015 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1941677/table/T4/ Table 4Circulating adiponectin, TNFα, cortisol, and FFA concentrations before and after the intervention.------------------------------------------ EX (n = 18) CR (n = 18) HL(n = 10)===Among group P------------------------------------------Cortisol, μg/mLBaseline 11.9 ± 4.1 15.4 ± 4.7 12.8 ± 2.7 Final 11.8 ± 4.9 11.4 ± 3.2 10.6 ± 3.1===0.30 Link to comment Share on other sites More sharing options...
Michael R Posted February 21, 2015 Report Share Posted February 21, 2015 Al Pater wrote: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1941677/pdf/nihms10828.pdf http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1941677/table/T4/ Table 4 Circulating adiponectin, TNFa, cortisol, and FFA concentrations before and after the intervention. ------------------------------------------ EX (n = 18) CR (n = 18) HL(n = 10)===Among group P ------------------------------------------ Cortisol, μg/mL Baseline 11.9 ± 4.1 15.4 ± 4.7 12.8 ± 2.7 Final 11.8 ± 4.9 11.4 ± 3.2 10.6 ± 3.1 0.30 Change −0.1 ± 4.4 −4.0 ± 4.1 −2.2 ± 4.2 Thanks, Al. However, this is from the CALERIE study, which was an obesity-correction trial rather than true CR, so I wouldn't put any real stock in it. Link to comment Share on other sites More sharing options...
greenbaum Posted March 2, 2015 Report Share Posted March 2, 2015 Serum or Saliva depends on why you want to measure Cortisol ? http://www.labrix.com/SalivaryHormoneTesting offers a Saliva test for a group of hormones, and of course explains why that is better than Serum Their test can check the level at 4 different times of the day I have used this to help correct Testosterone and Estrogen in a number of people Their Testosterone level correlates very well with the "morning glory" ! . Link to comment Share on other sites More sharing options...
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