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arwin77

Biomarker - Cortisol

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I'm wondering if anyone has thoughts about the appropriate upper limit for diurnal (morning) serum cortisol in CR.  I know it's supposed to be high, but I'm having trouble finding appropriate benchmarks.  My concern is -- how high?  And are there corresponding biomarkers that one might correlate with cortisol being too high such as glucose?

 

I seem to only find salivary.  Also, if anyone has any conversion (salivary --> serum) that might be helpful.

 

Thanks very much!

Edited by prophets

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Hi there (are you the same Prophets as on Longecity?),

 

I wish there were data from the WUSTL study in our cohort. The best I can find is from the Biosphere natural experiment:

 

F4.large.jpg

 

It looks like total cortisol climbed from 15 to 19 µg/dL during their period in the Biosphere, while cortisol binding globulin rose in response in the range of 3.1 to 3.3 mg/dL (someone could perhaps contribute a molar ratio conversion), keeping free cortisol hovering pretty narrowly at 2.0-2.1 µg/dL.(1)

 

Reference

1: Walford RL, Mock D, Verdery R, MacCallum T. Calorie restriction in biosphere 2: alterations in physiologic, hematologic, hormonal, and biochemical parameters in humans restricted for a 2-year period. J Gerontol A Biol Sci Med Sci. 2002 Jun;57(6):B211-24. PubMed PMID: 12023257.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1941677/table/T4/

Table 4
Circulating adiponectin, TNFα, cortisol, and FFA concentrations before and after the intervention.
------------------------------------------
 EX (n = 18) CR (n = 18) HL(n = 10)===Among group P
------------------------------------------
Cortisol, μg/mL
Baseline 11.9 ± 4.1 15.4 ± 4.7 12.8 ± 2.7 
Final 11.8 ± 4.9 11.4 ± 3.2 10.6 ± 3.1===0.30

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Al Pater wrote: 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1941677/pdf/nihms10828.pdf

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1941677/table/T4/

 

Table 4

Circulating adiponectin, TNFa, cortisol, and FFA concentrations before

and after the intervention.

------------------------------------------

EX (n = 18) CR (n = 18) HL(n = 10)===Among group P

------------------------------------------

Cortisol, μg/mL

x2003.gifBaseline 11.9 ± 4.1 15.4 ± 4.7 12.8 ± 2.7  

x2003.gifFinal 11.8 ± 4.9 11.4 ± 3.2 10.6 ± 3.1 0.30

x2003.gifChange −0.1 ± 4.4 −4.0 ± 4.1 −2.2 ± 4.2

 

Thanks, Al. However, this is from the CALERIE study, which was an obesity-correction trial rather than true CR, so I wouldn't put any real stock in it.

Edited by Michael R

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Serum or Saliva depends on why you want to measure Cortisol ?

 

http://www.labrix.com/SalivaryHormoneTesting offers a Saliva test for a group of hormones, and of course explains why that is better than Serum

Their test can check the level at 4 different times of the day

 

I have used this to help correct Testosterone and Estrogen in a number of people 

Their Testosterone level correlates very well with the "morning glory" ! 

 

.

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