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James Cain

Weekly research updates

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This week's newly-indexed CR-related research is available on PubMed here.
 
Titles:

  • SIRT1 Gain of Function Does Not Mimic or Enhance the Adaptations to Intermittent Fasting.
  • Hypothalamic Npy mRNA is correlated with increased wheel running and decreased body fat in calorie-restricted rats.
  • Reprogramming of energy metabolism as a driver of aging.
  • Angiotensin Converting Enzyme (ACE) Inhibitor Extends Caenorhabditis elegans Life Span.
  • Dietary restriction with and without caloric restriction for healthy aging.



#5 is by Valter Longo and is free full-text. It is short discussion of fasting or protein restriction as a potential means to get the benefits of CR without actually restricting calories.

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This week's newly-indexed CR-related research is available on PubMed here.
 
Titles:

  1. Ghrelin-AMPK Signaling Mediates the Neuroprotective Effects of Calorie Restriction in Parkinson's Disease.
  2. A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction.
  3. Deconstructing Dietary Restriction: A Case for Systems Approaches in Aging.
  4. Measuring aging rates of mice subjected to caloric restriction and genetic disruption of growth hormone signaling.
  5. Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging.
  6. Phylloquinone and Menaquinone-4 Tissue Distribution at Different Life Stages in Male and Female Sprague-Dawley Rats Fed Different VK Levels Since Weaning or Subjected to a 40% Calorie Restriction since Adulthood.
  7. Calorie Restriction-induced SIRT6 Activation Delays Aging by Suppressing NF-κB Signaling.
  8. Dietary restriction suppresses apoptotic cell death, promotes Bcl-2 and Bcl-xl mRNA expression and increases the Bcl-2/Bax protein ratio in the rat cortex after cortical injury.
  9. The effects of graded levels of calorie restriction: VI. Impact of short-term graded calorie restriction on transcriptomic responses of the hypothalamic hunger and circadian signaling pathways.
  10. Comparison of the effects of resveratrol and caloric restriction on learning and memory in juvenile C57BL/6J mice.


#9 is a continuation of a great series on CR. It's quite technical but worth the read. Free full-text.

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There were no new relevant article last week.

This week's newly-indexed CR-related research is available on PubMed here.
 
Titles:

  1. Calories or Protein? The effect of dietary restriction on lifespan in rodents is explained by calories alone.
  2. Calorie restriction in overweight older adults: Do benefits exceed potential risks?
  3. Safety of two-year caloric restriction in non-obese healthy individuals.
  4. From yeast to human: exploring the comparative biology of methionine restriction in extending eukaryotic life span.
  5. Reversibility of β-Cell-Specific Transcript Factors Expression by Long-Term Caloric Restriction in db/db Mouse.


#3 is another CALERIE report. There's a good discussion of it in our forums here.

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This week's newly-indexed CR-related research is available on PubMed here.
 
Titles:

  1. Biology of Healthy Aging and Longevity.
  2. Caloric restriction coupled with radiation decreases metastatic burden in triple negative breast cancer.

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This week's newly-indexed CR-related research is available on PubMed here.


 


Titles:


  1. Dietary restriction: could it be considered as speed bump on tumor progression road?

  2. A chromatin modifier integrates insulin/IGF-1 signalling and dietary restriction to regulate longevity.

  3. Human longevity: Genetics or Lifestyle? It takes two to tango.

  4. A Nutritional Approach to the Prevention of Cancer: from Assessment to Personalized Intervention.



#3, the abstract says ipocaloric which means hypocaloric. The authors are from Italy, and ipo- = hypo- in Italian.


#4. The full-text only makes a brief mention of CR and doesn't actually explain it, but I thought I'd include it here anyway because they directly say "Indeed, caloric restriction without malnutrition is associated to cancer prevention," despite not providing evidence. Perhaps this is just common knowledge now. :-)


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This week's newly-indexed CR-related research is available on PubMed here.


 


Titles:


  1. Nutrition and Energetics in Rodent Longevity Research.

  2. Changes in hunger and fullness in relation to gut peptides before and after 8 weeks of alternate day fasting.

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This week's newly-indexed CR-related research is available on PubMed here.


 


Titles:


  1. Nutritional ecology and the evolution of aging.

  2. Effect of calorie restriction on spontaneous physical activity and body mass in mice divergently selected for basal metabolic rate (BMR).

  3. Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging Molecules.

  4. Severe Calorie Restriction Reduces Cardiometabolic Risk Factors and Protects Rat Hearts from Ischemia/Reperfusion Injury.

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This week's newly-indexed CR-related research is available on PubMed here.


 


Titles:


  1. The effects of graded levels of calorie restriction: VII. Topological rearrangement of hypothalamic aging networks.

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This week's newly-indexed CR-related research is available on PubMed here.


 


Titles:


  1. Caloric restriction paradoxically increases adiposity in mice with genetically reduced insulin.

  2. Comparative idiosyncrasies in life extension by reduced mTOR signalling and its distinctiveness from dietary restriction.

  3. Effect of Calorie Restriction on Mood, Quality of Life, Sleep, and Sexual Function in Healthy Nonobese Adults: The CALERIE 2 Randomized Clinical Trial.

  4. Dietary Protein, Metabolism, and Aging.

  5. New Horizons: Dietary protein, ageing and the Okinawan ratio.

  6. The Four Layers of Aging.



#6 doesn't focus on CR, but it does mention it a few times. However, it's a pretty good review of the aging process and should be fairly well understood even by those without a heavy science background. It's not free full-text, but Sci-Hub can help with access!


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This week's newly-indexed CR-related research is available on PubMed here.


 


Titles:


  1. Nutritional limitation in early postnatal life and its effect on aging and longevity in rodents.

  2. Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway.

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This week's newly-indexed CR-related research is available on PubMed here.


 


Titles:


  1. Calorie restriction regulates circadian clock gene expression through BMAL1 dependent and independent mechanisms.

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This week's newly-indexed CR-related research is available on PubMed here.


 


Titles:


  1. Feast and Famine: Adipose Tissue Adaptations for Healthy Aging.

  2. Chemical activation of a food deprivation signal extends lifespan.

  3. DNA Damage: A Main Determinant of Vascular Aging.

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May I add one not listed here ?

 

Pharmacological Strategies to Retard Cardiovascular Aging (CR, Rapamycin, Metformin, Resveratrol, ACE inhibitors, Aspirin, Berberine ...)

Asbtract

Edited by tasbin

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