GenGenimney Posted August 7, 2015 Report Share Posted August 7, 2015 There seems to be some confusion about possible mechanisms for continuing fecundity in mice under CR into old age, and I've seen suggestions in various places that CR might theoretically extend fertility in women. This isn't possible. As far as reproduction goes...mice aren't human. Here's an overview of folliculogenesis: https://en.wikipedia.org/wiki/Folliculogenesis Other than the solid overview, a point of interest is under "number of follicles." The short version is this: Humans don't produce more follicles after birth, period. There is also a common misconception that I've seen that an anovulatory woman is somehow preserving/reserving her follicles for later recruitment. This also simply isn't true. Follicles are recruited continuously into the first stages of development roughly a year before ovulation. If they pass through the upper stages without being subject to the right dose of FSH for recruitment into antral follicles, they will simply suffer from atresia and die. Similarly, the "best" of the antral follicles--meaning the one that has the most FSH receptors at the time of FSH increase--will be the only one large enough to respond to a surge of LH and burst, causing ovulation. Amenorrhea from any cause doesn't prevent or slow or otherwise attenuate the first stage of follicle recruitment. Therefore, it has zero chance of either extending fertility or delaying menopause. Damage to the ovaries, often from a chemical insult, can lower the number of primordial follicles and can potentially speed up menopause because low ovarian reserve is a major trigger for menopause. Two major causes of a low number of primordial follicles are high androgens in utero and chemotherapy. Regardless of one's starting place, as the number of follicles for recruitment are depleted, so is a woman's fertility. This process begins in one's early 20s--yes, early 20s!--and is complete by age 45 in most women. Women need to understand that there is no benefit whatsoever from amenorrhea from any cause whatsoever to the aging process or to fertility length. That said, amenorrhea can be perfectly normal and healthy--obviously during pregnancy but also during breastfeeding--and there is considerable benefit by lowering the risk of "female" cancers in this type of amenorrhea. However, amenorrhea from PCOS or from low weight/exercise/stress is pathological. In the case of true, classic PCOS, it shows up with insulin insensitivity. In the case of low eight/exercise/stress, it can rapidly deplete bone density, which can cause crippling and even deadly complications beginning as early as shortly after menopause, which will occur the same number of years after puberty regardless of your menstruation status. Link to comment Share on other sites More sharing options...
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