sirtuin Posted December 25, 2015 Report Share Posted December 25, 2015 From an optimal health / longevity stance, I'm curious which sweeteners might work best. There's honey, which contains a fair amount of free fructose and is basically pure sugar + some minor antioxidants (although, my diet is generally packed with antioxidants.) There's coconut sugar / dark brown sugar / maple syrup, which are fairly similar to honey (or high-fructose corn syrup), but a bit more processed. Then, there's date sugar and molasses, which seem fairly similar to honey, but contain much more in the way of antioxidants and micronutrients. And finally, there's the more interesting sweeteners like Stevia, Monk Fruit, Xylitol, Erythritol, and others ("Just Like Sugar", Trehalose, etc.) For a while, I was fairly anti-sugar / anti-fructose in an attempt to maintain very low levels of small dense LDL, very low levels of triglycerides, and support metabolic health / insulin sensitivity, although lately I'm coming around to a higher intake of fructose+sucrose from fruits along with a higher intake of glucose+starches as I'm finding ways to attenuate their effects on blood sugar. I don't usually buy into zero calorie sweeteners, but I've been experimenting a bit with sugar alcohols / stevia and they seem to work fine for my purposes as well. https://en.wikipedia.org/wiki/Daf-2 Research into the interaction between diet and the insulin/IGF-1 pathway has shown sugar intake to be negatively correlated with DAF-16 activity and longevity. One study found that glucose ingestion reduced the rate of dauer formation and shortened the life-spans of DAF-2 knock-downs to resemble that of normal C. elegans, suggesting that DAF-16 mediated gene expression associated with longevity is suppressed by glucose ingestion Wild type C. elegans fed a diet that included 2% glucose showed reduced Daf-16 activity and lifespan was shortened by 20% compared to worms fed on glucose-free media. These findings raise the possibility that a low-sugar diet might have beneficial effects on life span in higher organisms. https://en.wikipedia.org/wiki/Cynthia_Kenyon#Personal_diet Kenyon's research prompted her to make personal dietary changes. She stopped eating high glycemic index carbohydrates when she discovered that putting sugar on the worms' food shortened their lifespans. Kenyon follows a low glycemic index diet similar to the Atkins diet and the South Beach Diet. No desserts. No sweets. No potatoes. No rice. No bread. No pasta. When I say ‘no,’ I mean ‘no, or not much,’ she notes. Instead, eat green vegetables. Eat the fruits that aren't the sweet fruits, like melon. Bananas? Bananas are a little sweet. Meat? Meat, yes, of course. Avocados. All vegetables. Nuts. Fish. Chicken. That's what I eat. Cheese. Eggs. And one glass of red wine a day. But the diet is unproven, she cautions, and she's not recommending it for all. Nevertheless, she's pleased with its performance for her. 'I have a fabulous blood profile. My triglyceride level is only 30. Am I better off sticking to sugar-based sweeteners (like honey?), or including some mix of sugar alcohols (xylitol or erythritol?), or including some stevia, for my health / longevity goals? Link to comment Share on other sites More sharing options...
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