AlPater Posted August 18, 2016 Report Share Posted August 18, 2016 Personally, I do not think that a topic not even in Wikipedia merits little attention. But anyway, the below seems to add something to those that might be interested. It is just a summary of mechanisms involved in BAT and uncoupling protein with thermogenesis, weight loss and such. Perspective Metabolism Weiwei Fan, Ronald Evans Science 19 Aug 2016: Vol. 353, Issue 6301, pp. 749-750 DOI: 10.1126/science.aah6189 http://sci-hub.cc/10.1126/science.aah6189 An enzyme steps up to BAT as a potential mitochondrial uncoupler Summary Treatment of obesity and obesity-associated diseases has been challenging, with the first potential cure claimed in 1934 with the protonophore 2,4-dinitrophenol (DNP). This chemical dissipates mitochondrial membrane potential into heat production and is extremely effective in boosting metabolic rate and promoting weight loss (1). However, severe side effects, including cataract formation, cardiotoxicity, overheating, and death, prevented its further use (2). In a recent study, Long et al. (3) report that a secreted enzyme called peptidase M20 domain containing 1 (PM20D1) converts fatty acids and amino acids into N-acyl amino acids, which directly uncouple mitochondrial membrane potential in a way similar to that of DNP, to increase energy expenditure without physical movement. Might these endogenous metabolites be a safe alternative to chemical uncouplers, facilitating effortless fat burning without a fatal consequence? ------------------------------------------ The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria. Long JZ, Svensson KJ, Bateman LA, Lin H, Kamenecka T, Lokurkar IA, Lou J, Rao RR, Chang MR, Jedrychowski MP, Paulo JA, Gygi SP, Griffin PR, Nomura DK, Spiegelman BM. Cell. 2016 Jul 14;166(2):424-35. doi: 10.1016/j.cell.2016.05.071. Epub 2016 Jun 30. PMID: 27374330 http://sci-hub.cc/10.1016/j.cell.2016.05.071 Quote Link to comment Share on other sites More sharing options...
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