Cold Exposure & Other Mild Stressors for Increased Health & Longevity

[mccoy]

I take the above post back. Today the temp rose  above  16°C. In the morning, it really felt like the world skipped 3.5 months and we entered middle March. Weird!

[BrianA]

It appears cold has a negative effect on the nose's immune response via a reduced extracellular vesicles response. Scientists report wearing a mask can avoid this side effect of cold exposure.

 

Scientists finally know why people get more colds and flu in winter

https://www.cnn.com/2022/12/06/health/why-winter-colds-flu-wellness/

[Sibiriak]

Short popular press article:

Cold Exposure May Inhibit Cancer Growth By 'Hijacking' Glucose Storage

It cites this Aug. 2022 study:

Brown-fat-mediated tumour suppression by cold-altered global metabolism

Quote

In a pilot human study, mild cold exposure activates a substantial amount of BAT in both healthy humans and a patient with cancer with mitigated glucose uptake in the tumour tissue. These findings provide a previously undescribed concept and paradigm for cancer therapy that uses a simple and effective approach. We anticipate that cold exposure and activation of BAT through any other approach, such as drugs and devices either alone or in combination with other anticancer therapeutics, will provide a general approach for the effective treatment of various cancers.

 

 

Edited December 21, 2022 by Sibiriak

[mccoy]

Sibiriak, are you being able to practice CE now in Siberia? Here today, Christmas day, we had 5°C minimum and 14°C max, no wind, sunshine. A few minutes ago, at sunset, with 11 °C and 100% humidity, barechested I just started to feel a pleasant coolness working outside.

I doubt that in southern Europe up to now it has been possible to activate BAT metabolism. Cold showers may help, if prolonged for at least 10 minutes.

[Sibiriak]

1 hour ago, mccoy said:

Sibiriak, are you being able to practice CE now in Siberia?

Hell yeah!

[Sibiriak]

That was was in November.   December has been mostly in the -15 to -27C range.  It has warmed up recently to -8 to -15C, but forecast to go back to -20 to -30C by the end of next week.

I'm definitely doing a lot of CE.      Tap water comes straight from the Yenisey river and is really, really cold.

 

[mccoy]

Sibiriak, it is in a way reassuring that Siberia keeps being cold, at least in the winter!

Tonight the minimum here was 9°C, at least humidity was 100%.

[AlanPater]

"Activate your “dive reflex.”

You know that movie moment when the main character runs away from a stressful situation and into a public bathroom? When they take a deep breath and splash cold water from the sink on their face as a way to show the audience that they really need to calm down? Melodramatic as it may seem, a version of this grounding technique could actually help you in real life, since splashing cold water on your face is a way to activate the “dive reflex,” your body’s natural way of focusing blood and oxygen to your vital organs when you’re submerged in water.²

“This tool can be helpful when people are starting to kind of panic—they’re going into a presentation or a meeting they’re really nervous about and they’re feeling acute anxiety due to a stressor,” Nicole Murray, PsyD, clinical director and CEO at telehealth therapy group Cultured Space, tells SELF. Cold water on your face can calm your autonomic nervous system, decreasing your heart rate and slowing your breathing.  

https://www.self.com/story/stress-relief-activities?utm_source=pocket-newtab

"

[Gordo]

Cold is beneficial for healthy aging

[Saul]

Nice find.

  --  Saul

[mccoy]

Just today I discovered that Wim Hof is no longer the recordman for ice immersion.

The Polish engineer and athlete Valerjan Romanovski has established the record at 3 hours, 28 seconds. Impressing to say the least. Far longer than anyone previously managed. And Coming out alive. Pls watch the video!

 

Edited December 10, 2023 by mccoy

[mccoy]

Also, bathing outside in water in a  minus 50°C environment. But he is a Siberian...

 

[Ron Put]

I am still far from convinced and just came across this, don't think it was posted before;


Ambient temperature affects thrombotic potential at rest and following exercise

Conclusion: Coagulation potential is elevated during exposure to cold temperatures. These data suggest that risk of an ischemic event may be elevated in the cold.

[Gordo]

On 12/10/2023 at 9:35 PM, Ron Put said:

These data suggest that risk of an ischemic event may be elevated in the cold.

You don't think outside the box much, do you? This problem is easily solved with a simple pair of socks. Never forget socks! 

 

[mccoy]

On 12/23/2023 at 8:58 PM, Gordo said:

This problem is easily solved with a simple pair of socks. Never forget socks! 

....Gordo, do not let's forget the powerful anti-trombotic synergy of a white bathrobe before the plunge and a cup of warm coffee!

[Gordo]

 

[Gordo]

Full version: 

 

[Gordo]

There are some interesting comments in the above vid, for example she mentions studies showing you can activate brown fat just by putting your hand alone into a bucket of cold water.  There is value in fluctuating your temperature throughout the day to build brown fat.  And sleeping in a cold room, even with clothes and a heavy blanket still works to activate brown fat as long as your face is exposed to the cold air. 

[Kenton]

21 hours ago, Gordo said:

There are some interesting comments in the above vid, for example she mentions studies showing you can activate brown fat just by putting your hand alone into a bucket of cold water.  There is value in fluctuating your temperature throughout the day to build brown fat.  And sleeping in a cold room, even with clothes and a heavy blanket still works to activate brown fat as long as your face is exposed to the cold air. 

I've very recently been formulating the same theories in my cold exposure, but never saw reports from others on them. In particular, often it seems my Oura ring measured HRV is higher the night after a great episode of CE. Now, in my day to day living, on certain days just my feet, or hands, or head (e.g., from surfing in various environments / conditions or from sleeping with the windows open when it got colder than anticipated) get veeery cold without my core body temp. seeming to be challenged much. On those certain days, my resulting Oura ring measured HRV seems to come-in high.

[Gordo]

Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomesCold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes

Lee, H.J., Alirzayeva, H., Koyuncu, S. et al. Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes. Nat Aging 3, 546–566 (2023). https://doi.org/10.1038/s43587-023-00383-4

Abstract

Aging is a primary risk factor for neurodegenerative disorders that involve protein aggregation. Because lowering body temperature is one of the most effective mechanisms to extend longevity in both poikilotherms and homeotherms, a better understanding of cold-induced changes can lead to converging modifiers of pathological protein aggregation. Here, we find that cold temperature (15 °C) selectively induces the trypsin-like activity of the proteasome in Caenorhabditis elegans through PSME-3, the worm orthologue of human PA28γ/PSME3. This proteasome activator is required for cold-induced longevity and ameliorates age-related deficits in protein degradation. Moreover, cold-induced PA28γ/PSME-3 diminishes protein aggregation in C. elegans models of age-related diseases such as Huntington’s and amyotrophic lateral sclerosis. Notably, exposure of human cells to moderate cold temperature (36 °C) also activates trypsin-like activity through PA28γ/PSME3, reducing disease-related protein aggregation and neurodegeneration. Together, our findings reveal a beneficial role of cold temperature that crosses evolutionary boundaries with potential implications for multi-disease prevention.