KHashmi317 Posted January 28, 2016 Report Share Posted January 28, 2016 From 26 Jan 2016 Nature weekly Podcast (about 07:49 min into the 'cast): "Megaworm: Scientists watch 100,000 worms live and die in a grand lifespan experiment" http://www.nature.com/nature/podcast/ The Podcast episode, particularly, goes into relevance and importance of CR in this megaworm study. In essence, CR is like a broad-spectrum life extender (i.e., it lessens risk of ALL tested diseases). Other LE interventions (besides CR) were also explored/tested. Not sure Al has posted this paper ;) Would be nice in PDF, as it's full o' infographics, as the thumbnails suggest! http://www.nature.com/nature/journal/vaop/ncurrent/full/nature16550.html The temporal scaling of Caenorhabditis elegans ageing Nicholas Stroustrup, Winston E. Anthony, Zachary M. Nash, Vivek Gowda, Adam Gomez, Isaac F. López-Moyado, Javier Apfeld & Walter Fontana Nature (2016) doi:10.1038/nature16550 Received 27 July 2015 Accepted 18 December 2015 Published online 27 January 2016 The process of ageing makes death increasingly likely, involving a random aspect that produces a wide distribution of lifespan even in homogeneous populations1, 2. The study of this stochastic behaviour may link molecular mechanisms to the ageing process that determines lifespan. Here, by collecting high-precision mortality statistics from large populations, we observe that interventions as diverse as changes in diet, temperature, exposure to oxidative stress, and disruption of genes including the heat shock factor hsf-1, the hypoxia-inducible factor hif-1, and the insulin/IGF-1 pathway components daf-2, age-1, and daf-16 all alter lifespan distributions by an apparent stretching or shrinking of time. To produce such temporal scaling, each intervention must alter to the same extent throughout adult life all physiological determinants of the risk of death. Organismic ageing in Caenorhabditis elegans therefore appears to involve aspects of physiology that respond in concert to a diverse set of interventions. In this way, temporal scaling identifies a novel state variable, r(t), that governs the risk of death and whose average decay dynamics involves a single effective rate constant of ageing, kr. Interventions that produce temporal scaling influence lifespan exclusively by altering kr. Such interventions, when applied transiently even in early adulthood, temporarily alter kr with an attendant transient increase or decrease in the rate of change in r and a permanent effect on remaining lifespan. The existence of an organismal ageing dynamics that is invariant across genetic and environmental contexts provides the basis for a new, quantitative framework for evaluating the manner and extent to which specific molecular processes contribute to the aspect of ageing that determines lifespan. Link to comment Share on other sites More sharing options...
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