How to reduce protein carbamylation levels?

[InquilineKea]

Does CR even help? It seems that urea is tied in with protein carbamylation levels, so I wonder if reducing protein consumption helps?

 

Important post from https://www.fightaging.org/archives/2015/12/protein-carbamylation-is-associated-with-aging.php

 

Quote:

Chemical reactions referred to as

nonenzymatic posttranslational modifications (NEPTMs)

, such as

glycoxidation

, are responsible for protein molecular aging. Carbamylation is a more recently described NEPTM that is caused by the nonenzymatic binding of

isocyanate

derived from

urea

dissociation

or

myeloperoxidase

-mediated

catabolism

of

thiocyanate

to free

amino groups

of proteins. This modification is considered an adverse reaction, because it induces alterations of protein and cell properties. It has been shown that carbamylated proteins increase in plasma and tissues during

chronic kidney disease

and are associated with deleterious clinical outcomes, but nothing is known to date about tissue protein carbamylation during aging.

To address this issue, we evaluated

homocitrulline

rate, the most characteristic carbamylation-derived product (CDP), over time in skin of mammalian species with different life expectancies. Our results show that carbamylation occurs throughout the whole lifespan and leads to tissue accumulation of carbamylated proteins. Because of their remarkably long half-life, matrix proteins, like

type I collagen

and

elastin

, are preferential targets. Interestingly, the accumulation rate of CDPs is inversely correlated with longevity, suggesting the occurrence of still unidentified protective mechanisms. In addition, homocitrulline accumulates more intensely than

carboxymethyl-lysine

, one of the major advanced glycation end products, suggesting the prominent role of carbamylation over glycoxidation reactions in age-related tissue alterations. Thus, protein carbamylation may be considered a hallmark of aging in mammalian species that may significantly contribute in the structural and functional tissue damages encountered during aging.