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Signatures of early frailty in the gut microbiota


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Thanks to Al Pater for posting the following two articles to our lists:


Signatures of early frailty in the gut microbiota.
Jackson M, Jeffery IB, Beaumont M, Bell JT, Clark AG, Ley RE, O'Toole PW, Spector TD, Steves CJ.
Genome Med. 2016 Jan 29;8(1):8. doi: 10.1186/s13073-016-0262-7.
PMID: 26822992



There was a striking negative association between frailty and gut microbiota diversity, underpinned by specific taxonomic associations. Whether these relationships are causal or consequential is unknown. Nevertheless, they represent targets for diagnostic surveillance, or for intervention studies to improve vitality in ageing.


Gut microbiota and aging.
O'Toole PW, Jeffery IB.
Science. 2015 Dec 4;350(6265):1214-5. doi: 10.1126/science.aac8469. Review.
PMID: 26785481



There is evidence that loss of gut microbiota diversity can occur and does affect the aging process.

Although not significantly associated with chronological aging, loss of diversity in the core microbiota groups is associated with increased frailty and reduced cognitive performance.



I sent in my sample to μBiome at the end of November. Still no results.... When I get them I'll report on my "diversity".



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