Dean Pomerleau Posted March 3, 2016 Report Share Posted March 3, 2016 All, Al posted a new review article  which discusses all the available evidence relating calorie restriction, protein restriction, and methionine restriction to bone health. It basically goes over many of the things we've discussed here before - like the fact that DEXA bone scanners aren't well-calibrated for very thin people, and that CRed organisms have lighter bones, but not necessarily bones that are lower in quality, or more fragile. I like the way they summarize in the free full text: In the pursuit of survival with enhanced growth and development, human beings have come to suffer the negative effects of excessive nutrition.Currently, it may be appropriate to reevaluate the possibility that dietary restriction actually shapes a skeletal system to a size or mass suitable for the organism rather than causes an unfavorable loss of bone mineral. A philosophy of achieving optimal bone quality may be more important than preserving maximal bone size/mass when considering skeletal health under various dietary restrictions. As I said, nothing really new, but it's nice to see all the reassuring evidence suggesting our skeletons aren't crumbling away as a result of CR. --Dean ------------  Ann N Y Acad Sci. 2016 Feb 16. doi: 10.1111/nyas.13004. [Epub ahead of print] Dietary restrictions, bone density, and bone quality.Huang TH(1), Ables GP(2).Author information:(1)Laboratory of Exercise, Nutrition and Bone Biology, Institute of PhysicalEducation, Health and Leisure Studies, National Cheng Kung University, Tainan,Taiwan. (2)Orentreich Foundation for the Advancement of Science, ColdSpring-on-Hudson, New York. Free full text: http://onlinelibrary.wiley.com/doi/10.1111/nyas.13004/epdf Caloric restriction (CR), protein restriction (PR), and specific amino acidrestriction (e.g., methionine restriction (MR)) are different dietaryinterventions that have been confirmed with regard to their comprehensivebenefits to metabolism and health. Based on bone densitometric measurements,weight loss induced by dietary restriction is known to be accompanied by reducedareal bone mineral density, bone mass, and/or bone size, and it is consideredharmful to bone health. However, because of technological advancements in bonedensitometric instruments (e.g., high-resolution X-ray tomography), dietaryrestrictions have been found to cause a reduction in bone mass/size rather thanvolumetric bone mineral density. Furthermore, when considering bone quality, bonehealth consists of diverse indices that cannot be fully represented bydensitometric measurements alone. Indeed, there is evidence that moderate dietaryrestrictions do not impair intrinsic bone material properties, despite thereduction in whole-bone strength because of a smaller bone size. In the presentreview, we integrate research evidence from traditional densitometricmeasurements, metabolic status assays (e.g., energy metabolism, oxidativestresses, and inflammatory responses), and biomaterial analyses to providerevised conclusions regarding the effects of CR, PR, and MR on the skeleton.© 2016 New York Academy of Sciences.PMID: 26881697 Link to comment Share on other sites More sharing options...
This topic is now archived and is closed to further replies.