There is a new paper out  (popular account) that seems to me to do a pretty good job summarizing what we know about the different causes of aging. They have the same perspective as Aubrey, Michael & SENS - namely that at its root aging is a result of metabolic damage accumulation. But they appear to have a slightly different taxonomy than Aubrey's "7 deadly causes", although I'll leave it to Michael to map between the two. Here is there graphic showing the "Hallmarks of Aging":
One thing that jumped out at me (and that I've highlighted above in yellow) was the role peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC1α) appears to play in the various hallmarks of aging. In fact, a drop in PGC1α signalling is implicated in four of the nine hallmarks of aging. This interests me, because PGC1α promotes mitochondria biogenesis, and is upregulated by cold exposure , as we've seen many times on the cold exposure thread.
Sadly, the authors don't mention cold exposure as a potential means to ameliorate the aging process. Instead they focus on CR, amino-acid restriction, CR-mimetics, time-restricted feeding, and exercise as the most promising longevity interventions. Oh well, someday the benefits of cold exposure will be more widely recognized.
Overall it's an fascinating paper covering both the mechanisms of aging and (some of) the best ideas we have for what can be done about it today.
 Cell 166, August 11, 2016
Metabolic Control of Longevity
PGC-1alpha: a key regulator of energy metabolism.
Liang H(1), Ward WF.
(1)Department of Cellular and Structural Biology, Audie Murphy Veterans
Administration Medical Center and University of Texas Health Science Center, San
Antonio, Texas 78229-3900, USA.
Peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha is a
member of a family of transcription coactivators that plays a central role in the
regulation of cellular energy metabolism. It is strongly induced by cold
exposure, linking this environmental stimulus to adaptive thermogenesis.
PGC-1alpha stimulates mitochondrial biogenesis and promotes the remodeling of
muscle tissue to a fiber-type composition that is metabolically more oxidative
and less glycolytic in nature, and it participates in the regulation of both
carbohydrate and lipid metabolism. It is highly likely that PGC-1alpha is
intimately involved in disorders such as obesity, diabetes, and cardiomyopathy.
In particular, its regulatory function in lipid metabolism makes it an inviting
target for pharmacological intervention in the treatment of obesity and Type 2