CR extends LS 3x in "progeria" mice (Nature podcast/interview)

[KHashmi317]

Pretty big/important CR news, so I'm sure many of you have seen the study by now.

It was a major segment in Nature (journal) podcast this week with interview of paper author (click play for audio at 14:58)

 

Article/paper here:

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature19329.html

 

 

Also see related/recent publ. here:

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature19427.html

 

 

[Dean Pomerleau]

Thanks Khurram, and nice to hear from you.

 

Forgive my skepticism, but what makes you characterize this study as "Pretty big/important CR news" might I ask?

 

It looks to me like another one of those studies that Michael always criticizes, in which researchers take f*cked up mice and make them live (marginally) longer through some intervention that correct their condition, but doesn't necessarily have any implication for slowing aging in normal, healthy animals (to say nothing of humans).

 

The fact that the intervention in this case was CR doesn't seem to me to make it any more significant than the typical cases.

 

Thoughts?

 

--Dean

[KHashmi317]

 

It looks to me like another one of those studies that Michael always criticizes, in which researchers take f*cked up mice and make them live (marginally) longer through some intervention that correct their condition, but doesn't necessarily have any implication for slowing aging in normal, healthy animals (to say nothing of humans).

 

I agree, there is no "clean" way to investigate.

That said, for THIS study, the investigators took progeria genetic samples from humans, and based their genetic intervention (in mice; i.e., same genes, TTBOMK) on those humans samples.

I think what may be more important is that progeria is extremely rare in humans, so any study based on this condition is NOT "Pretty big/important CR news" ;-)