Gordo Posted December 16, 2016 Report Share Posted December 16, 2016 I'm sure the hype is overstated, and like so many other studies they were working with genetically damaged mice, but still it is encouraging to at least see research in this area and some crumbs of progress. Scientists reverse ageing in mammals and predict human trials within 10 years Link to comment Share on other sites More sharing options...
TomBAvoider Posted December 16, 2016 Report Share Posted December 16, 2016 Yeah, I saw that story floating around today, but I can't make heads or tails of it. Does the 30% life extension apply only to the accellerated aging mice? If yes, then I guess good for the premature aging mice - but all it does is correct the underlying pathology. If it did it in normal lifespan mice and extended that by another 30% that would be something to write home about. Also, if it rejuvenates the cells by bringing them to an earlier stage of development, why couldn't you keep doing that over, and over again - so if you can reverse aging, then every time you hit a certain age you could just reverse again... right? If not, and you can only do that once, I guess that's still useful (in a normal lifespan organism). In short, it's hard to tell just what these guys have accomplished. Plus, there is always the issue of neural tissue in the brain - at some point you are at risk of losing your identity if there is too much replacement of tissue that forms your memories and the like. Bottom line: interesting, but way too little info on display here. Link to comment Share on other sites More sharing options...
Gordo Posted December 16, 2016 Author Report Share Posted December 16, 2016 Yes, that's pretty much what I was thinking when I read it... Let's see what it does to some real mice first at least. Link to comment Share on other sites More sharing options...
AlPater Posted December 16, 2016 Report Share Posted December 16, 2016 https://www.crsociety.org/topic/12032-aging-is-reversible%E2%80%94at-least-in-human-cells-and-live-mice/ In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming Online Extra Alejandro Ocampo, Pradeep Reddy, Paloma Martinez-Redondo, Aida Platero-Luengo, Fumiyuki Hatanaka, Tomoaki Hishida, Mo Li, David Lam, and others Cell, Vol. 167, Issue 7, p1719–1733.e12 Published in issue: December 15, 2016 http://www.cell.com/cell/fulltext/S0092-8674(16)31664-6 Highlights •Partial reprogramming erases cellular markers of aging in mouse and human cells •Induction of OSKM in progeria mice ameliorates signs of aging and extends lifespan •In vivo reprogramming improves regeneration in 12-month-old wild-type mice Summary Aging is the major risk factor for many human diseases. In vitro studies have demonstrated that cellular reprogramming to pluripotency reverses cellular age, but alteration of the aging process through reprogramming has not been directly demonstrated in vivo. Here, we report that partial reprogramming by short-term cyclic expression of Oct4, Sox2, Klf4, and c-Myc (OSKM) ameliorates cellular and physiological hallmarks of aging and prolongs lifespan in a mouse model of premature aging. Similarly, expression of OSKM in vivo improves recovery from metabolic disease and muscle injury in older wild-type mice. The amelioration of age-associated phenotypes by epigenetic remodeling during cellular reprogramming highlights the role of epigenetic dysregulation as a driver of mammalian aging. Establishing in vivo platforms to modulate age-associated epigenetic marks may provide further insights into the biology of aging. Link to comment Share on other sites More sharing options...
Gordo Posted March 25, 2017 Author Report Share Posted March 25, 2017 More progress with this: http://www.sciencemag.org/news/2017/03/molecule-kills-elderly-cells-reduces-signs-aging-mice https://www.theguardian.com/science/2017/mar/23/purging-the-body-of-retired-cells-could-reverse-ageing-study-shows Link to comment Share on other sites More sharing options...
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