TomBAvoider Posted January 7, 2017 Report Share Posted January 7, 2017 Biomarker signatures of aging Authors Paola Sebastiani, Bharat Thyagarajan, Fangui Sun, Nicole Schupf, Anne B. Newman, Monty Montano, Thomas T. Perls First published: 6 January 2017 DOI: 10.1111/acel.12557 Summary Because people age differently, age is not a sufficient marker of susceptibility to disabilities, morbidities, and mortality. We measured nineteen blood biomarkers that include constituents of standard hematological measures, lipid biomarkers, and markers of inflammation and frailty in 4704 participants of the Long Life Family Study (LLFS), age range 30–110 years, and used an agglomerative algorithm to group LLFS participants into clusters thus yielding 26 different biomarker signatures. To test whether these signatures were associated with differences in biological aging, we correlated them with longitudinal changes in physiological functions and incident risk of cancer, cardiovascular disease, type 2 diabetes, and mortality using longitudinal data collected in the LLFS. Signature 2 was associated with significantly lower mortality, morbidity, and better physical function relative to the most common biomarker signature in LLFS, while nine other signatures were associated with less successful aging, characterized by higher risks for frailty, morbidity, and mortality. The predictive values of seven signatures were replicated in an independent data set from the Framingham Heart Study with comparable significant effects, and an additional three signatures showed consistent effects. This analysis shows that various biomarker signatures exist, and their significant associations with physical function, morbidity, and mortality suggest that these patterns represent differences in biological aging. The signatures show that dysregulation of a single biomarker can change with patterns of other biomarkers, and age-related changes of individual biomarkers alone do not necessarily indicate disease or functional decline. Link to comment Share on other sites More sharing options...
Saul Posted January 10, 2017 Report Share Posted January 10, 2017 What are the biomarkers being discussed? Summary just gives "biomarkers numbers". -- Saul Link to comment Share on other sites More sharing options...
TomBAvoider Posted January 10, 2017 Author Report Share Posted January 10, 2017 The link in my post leads to the full text, where you'll find the biomarkers measured. Link to comment Share on other sites More sharing options...
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