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Akkermansia muciniphila


Anyone have a mainstream (non-piggy-capitalistically greed-driven) source for this evidently beneficial bacteria?




Immune system uses gut bacteria to control glucose metabolism


January 10, 2017


Researchers at Oregon State University and other institutions have discovered an important link between the immune system, gut bacteria and glucose metabolism – a “cross-talk” and interaction that can lead to type 2 diabetes and metabolic syndrome when not functioning correctly.


The findings, published today in Nature Communications, are one example of how different mammalian systems can affect each other in ways not previously understood.


A better understanding of these systems, researchers say, may lead to new probiotic approaches to diabetes and other diseases.


The research also shows the general importance of proper bacterial functions in the gut and the role of one bacteria in particular – Akkermansia muciniphila – in helping to regulate glucose metabolism.


This bacteria’s function is so important, scientists say, that it has been conserved through millions of years of evolution to perform a similar function in both mice and humans.


“We’re discovering that in biology there are multiple connections and communications, what we call cross-talk, that are very important in ways we’re just beginning to understand,” said Dr. Natalia Shulzhenko, an assistant professor in the OSU College of Veterinary Medicine, and one of the corresponding authors on this study.


“It’s being made clear by a number of studies that our immune system, in particular, is closely linked to other metabolic functions in ways we never realized. This is still unconventional thinking, and it’s being described as a new field called immunometabolism.”


“Through the process of evolution, mammals, including humans, have developed functional systems that communicate with each other, and microbes are an essential part of that process.”


It had been previously observed that an immune mediator – one type of interferon, or signaling protein called IFN-y – can affect the proper function of glucose metabolism.


IFN-y helps fight several pathogens and infections, but a decrease in its levels can lead to improvement in glucose metabolism. However, this actual process has not been understood.


“Before this, no one had a clue exactly how IFN-y affected glucose tolerance,” said Andrey Morgun, an assistant professor in the OSU College of Pharmacy and also a corresponding author on the study.


“The involvement of microbes had not really been considered. But with the help of a statistical model and an approach we call a transkingdom network, we were able to pinpoint some likely bacterial candidates.”


The bacteria A. muciniphila, was found to play a critical role in this communication process – in their study, the scientists called it a “missing link.”


Research showed that mice specially bred with reduced levels of IFN-y had higher levels of A. muciniphila, and significantly improved glucose tolerance. When IFN-y levels increased, A. muciniphila levels declined, and glucose tolerance was reduced.


Similar observations were also made in humans. It’s been observed, for instance, that athletes who are extremely fit have high levels of the gut bacteria A. muciniphila, which is a mucus-degrading bacteria.


The research makes clear that two systems once believed to be functionally separate – immunity and glucose metabolism – are, in fact, closely linked, and the bridge can be provided by gut bacteria.


There’s probably more than one bacteria involved in this process of communication and metabolic control, researchers said.


The gut harbors literally thousands of microbes that appear to function almost as a metabolically active organ, emphasizing the critical importance of gut bacterial health.


Bacteria-mediated communication, of course, is just one part of complex human systems – issues such as proper diet, exercise, and appropriate weight control are all still important, the researchers said.

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So to perhaps increase levels of Akkermansia muciniphila (if that's something you'd like to do) then feed the bacteria what they might like to eat: pomegranate, prebiotics, mucin (kiwi feed mucin?), N-acetyl-D-glucosamine, and maybe damned glutamine.


And if you're a rodent, you're in luck because maybe just maybe squeak hard enough and get a metformin prescription from your whisker-be-raised mouse doctor:


Gut Microbiota and Metabolic Disorders



"...Metformin can also affect the intestinal microbiota of mammals. We have demonstrated that metformin is able to affect the mouse microbiota and increase the abundance of Akkermansia muciniphila, a mucin-degrading G (-) anaerobes, in the gut of experimental mice fed a HFD (Fig. 2) [34]. We also observed that the administration of A. muciniphila had similar beneficial metabolic effects to that of metformin administration: (1) increased the number of mucin-producing goblet cells was similarly found after the administration of metformin or A. muciniphila; (2) diminished regulatory T (Treg) cell numbers and elevated interleukin 1β (IL-1β) or IL-6 mRNA expression in the visceral adipose tissue of mice fed a HFD were similarly reversed after the administration of metformin or A. muciniphila. Mucin has recently been shown to enhance delivery of tolerogenic immunoregulatory signal to the intestinal epithelium by forming galectin-3-dectin-1-FcγRIIB complex besides its classical role as a physical barrier [35] This study therefore underscores that drugs, such as metformin, might exert therapeutic effects, at least in part by modulating the gut micriobiota..."


Maybe too go metformin if you're an obese mouse looking to grow your Akkermansia muciniphila with metformin prescriptions from your equally obese mouse primary care physician (I totally see a mouse-inspired Wes Anderson film here, think it up like a Fantastic Mr. Fox):


An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice.


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