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Mechanism

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Mechanism, Longo allows 2-3 cups of green tea during his FMD.

 

I'd venture to say that the anti-insulinemic effect of IF is not impaired by unsweetened hearbal teas, unless their inherent carbs content is significant (unlikely hypothesis).

 

Decreasing blood insulin (and concurrently IGF-1) downregulates the mTORC1 complex by inhibiting the PIK3-Akt pathway (which inhibits the TSC1/TSC2  constraint on rheb). 

 

IF also decreases the amminos/Leucine signal, which is necessary to activate mTORC1, and increases probably AMPK (less blood glucose), an mTOR inhibitor by the middleman of TSC1/TSC2.

 

The rag GTPases and Rhab complex must both be activated to activate mTORC1 and its downstream cascade of metabolic reactions, unfavourable to longevity if overly active.

 

Bottomline, from the standpoint of mTOR, all main activating signals are decreased, so regular IF appears to be a longevity booster.

 

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Edited by mccoy

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After the mTOR premise, I read the linked article, which also concurs that serum insulin is decreased by IF. Now:

 

 

 

We also found that plasma insulin levels decreased as a result of IF (the intermittent fasting diet), but not IFAO (the intermittent fasting with antioxidant supplementation diet). This suggests that the IF diet may have a beneficial effect on glucose metabolism by lower insulin levels, and perhaps have an anti-diabetic effect. Furthermore, the finding that IFAO did not lower insulin levels suggests that the insulin-lowering effects might be stimulated by IF-induced oxidative stress, which is quenched by the further antioxidant supplementation.”

 

I'd be interested to know the quantity of antioxidant supplements in IFAO that presumably interferes with the IF-induced oxydative stress.

 

Besides, if the insulin IGF-1 signal is mantained in presence of many antioxidants, what about the other signals? AFAIK, without a significant amminos and leucine signal, mTOR is not translated to the lysosome surface and cannot be activated, since rheb resides there.

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I have always wondered why our liver gets rid of anti-inflammatory compounds from bloodstream rigorously. For example, if we eat turmeric with black pepper, bio-availability of curcumin increases as piperine interferes liver's ability to degrade curcumin. This leads me to believe that in its natural state, our body doesn't need external antioxidants, phenols etc. andit only works if there is something to fix. This is one of the reason why I don't buy the proposed health benefits of EVOO. I still don't find any evidence that if you are very healthy (I mean eating very healthy almost exclusively from plant sources, satisfying all RDAs etc.), will it give you additional benefit? It works on a population base since more than 99% of the population don't eat healthy, and replacing some of the calories by more healthier than that of course shows benefit. It's just relative. This is also valid for green tea, berries, herbs, spices and so on. I eat all the things I mentioned though since we need to eat something anyway.

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I tried recently to follow an IF of 16:8  type, skipping breakfast. I did for about 10 days, at the end I got used but 1) I noticed that I eat more in lunch and dinner and was more difficult to control the consumption of fruit  2) I was not able to continue to do the weekly fasting of 36 hours I do usually. 

So I decided to stick to my usual plan of eating three times a day and having one a week 36 hours fasting.

very interesting the information about possible conflicts between tea and anti oxidants. In the FMD by Longo I noticed the use of hibiscus tea, but in some part hte information is contradictory, because I read also that he suggested to not drink coffee etc. I use to take curcuma pills in low doses, maybe I will dismiss the use of it before and during fasting. thank you.

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I have always wondered why our liver gets rid of anti-inflammatory compounds from bloodstream rigorously. For example, if we eat turmeric with black pepper, bio-availability of curcumin increases as piperine interferes liver's ability to degrade curcumin. 

 

Burak, I often use together black pepper and turmeric powder on vegetables. Yesterday, my cauliflowers were literally buried under a yellow blanket of turmeric and black grains of pepper. Is that instinct or serendipity? Glad that the combo is so synergic though.

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For anti-inflammatory benefits of herbs and spices these two videos are very nice if you haven't watch them already and you can also check referenced studies for further information:

 

http://nutritionfacts.org/video/which-spices-fight-inflammation/

http://nutritionfacts.org/video/spicing-up-dna-protection/

 

Turmeric is very effective even for small doses (0.2g per day). I don't know if there is negative side effects for too much curcumin in the blood but I almost always get headaches when I accidentally put too much turmeric with too much black pepper to my tomato sauce. There could be another reason but I'm not sure, or maybe I have low body weight and fat and with the addition of black pepper it could raise to some dangerous levels rapidly and interfere with other necessary metabolic inflammatory pathways.

Edited by Burak

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One possible reason for Longo to rule out tea and coffee in his FMD may be the ergogenic properties of such drinks, which may interfere with the anti-inflammatory and regeneration mechanisms

Edited by mccoy

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