TomBAvoider Posted June 6, 2017 Report Share Posted June 6, 2017 Nice overview [of CR and Exercise], MR! With time, I've grown ever more skeptical about extrapolating almost anything from rodents to humans. It's gotten so bad, that when I see a paper that says "in mice" or rats, I don't even bother to read it. To me, studies done in mice or rats apply to mice or rats, and that's that - and only to a given strain of rodent. I am curious about the tension between lifespan and healthspan. It was always assumed commonsensically, that you lived longer, because you are healthier - it seems so obvious, it's almost a tautology. I remember, back in the day, you yourself, MR, have said things to that effect. But I think there's more and more evidence that this just ain't so. Starting with the observation that people reach the extreme old age status along different paths - there are the disease avoiders, the survivors and the copers, the postponers. If they all reach roughly the same age, then it clearly mitigates against the idea of healthspan being the only determinant of lifespan. That of course is complicated by genetic potential, in the same way that f.ex. a short lived species individual may be healthy but still have a short life span. So ideally there is only one way of ascertaining that, and it would be in the same individual - does health status irrevocably determine lifespan? Or perhaps, it might also be true that you could be a fairly sickly individual and live about as long as you'd live as a healthy one, with the only difference being QOL. It might be along a spectrum - if you are sick to a large enough degree it would affect your lifespan, but anything outside of some treshold is irrelevant - you're just a healthier or less healthy corpse having live a given amout of time. The squaring of the curve question wrt. exercise therefore is another way of addressing the question of how close the relationship between lifespan and healthspan is. Link to comment Share on other sites More sharing options...
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