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Rejuvenation drug J147


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Science Daily has an article about an Alzheimer's drug that rejuvenating side effects.  https://www.sciencedaily.com/releases/2018/01/180109090917.htm

 

the drug binds to a protein found in mitochondria ... it makes aging cells, mice and flies appear more youthful.

 

 J147 is a modified version of a molecule found in the curry spice curcumin. In the years since, the researchers have shown that the compound reverses memory deficits, potentiates the production of new brain cells, and slows or reverses Alzheimer's progression in mice.

 

They identified the molecular target of J147 as a mitochondrial protein called ATP synthase that helps generate ATP-the cell's energy currency-within mitochondria. They showed that by manipulating its activity, they could protect neuronal cells from multiple toxicities associated with the aging brain.

 

Further experiments revealed that modulating activity of ATP synthase with J147 changes the levels of a number of other molecules-including levels of ATP itself-and leads to healthier, more stable mitochondria throughout aging and in disease.

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Did came across this paper, after reading and searching info about the disappointing message from Pfizer, halting Alzheimer's research. Since I take curcumin lately, trying to relief some discomforting joint pains, I was a bit more interested. 

 

https://www.salk.edu/news-release/alzheimers-drug-turns-back-clock-powerhouse-cell/

 

Have a nice day, Ruud Marcus

 

LA JOLLA—The experimental drug J147 is something of a modern elixir of life; it’s been shown to treat Alzheimer’s disease and reverse aging in mice and is almost ready for clinical trials in humans. Now, Salk scientists have solved the puzzle of what, exactly, J147 does. In a paper published January 7, 2018, in the journal Aging Cell, they report that the drug binds to a protein found in mitochondria, the energy-generating powerhouses of cells. In turn, they showed, it makes aging cells, mice and flies appear more youthful.

 

“This really glues together everything we know about J147 in terms of the link between aging and Alzheimer’s,” says Dave Schubert, head of Salk’s Cellular Neurobiology Laboratory and the senior author on the new paper. “Finding the target of J147 was also absolutely critical in terms of moving forward with clinical trials.”

Schubert’s group developed J147 in 2011, after screening for compounds from plants with an ability to reverse the cellular and molecular signs of aging in the brain. J147 is a modified version of a molecule (curcumin) found in the curry spice turmeric. In the years since, the researchers have shown that the compound reverses memory deficits, potentiates the production of new brain cells, and slows or reverses Alzheimer’s progression in mice. However, they didn’t know how J147 worked at the molecular level.

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  • 2 weeks later...

Science Daily has an article about an Alzheimer's drug that rejuvenating side effects.  https://www.sciencedaily.com/releases/2018/01/180109090917.htm

 

the drug binds to a protein found in mitochondria ... it makes aging cells, mice and flies appear more youthful.

 

Yeah, not really. The lifespan effect is only in C. elegans, and the mouse data is on mice with severe oxidative stress: no surprise, antioxidants are good when you're bombarded with horrendous levels of ROS. Ignore it until someone does studies in normal, otherwise-healthy mammals.

 

Good, one more reason to eat turmeric...

 

I doubt very much that you can extrapolate the results to turmeric, between this being a tweaked molecule and turmeric's very low bioavailabilty — plus mice's colonic microflora generating different metabolites from phenolics than in humans.

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Thanks Michael for reminding us about the difference between (genetically selected) mice and humans. I didn't know about the microflora and that's yet another interesting factor of differentiation.

 

Turmeric rules just the same !!  Of course it's a fixed couple with piperine...

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