Guest Cory Posted January 10, 2018 Report Share Posted January 10, 2018 Science Daily has an article about an Alzheimer's drug that rejuvenating side effects. https://www.sciencedaily.com/releases/2018/01/180109090917.htm the drug binds to a protein found in mitochondria ... it makes aging cells, mice and flies appear more youthful. J147 is a modified version of a molecule found in the curry spice curcumin. In the years since, the researchers have shown that the compound reverses memory deficits, potentiates the production of new brain cells, and slows or reverses Alzheimer's progression in mice. They identified the molecular target of J147 as a mitochondrial protein called ATP synthase that helps generate ATP-the cell's energy currency-within mitochondria. They showed that by manipulating its activity, they could protect neuronal cells from multiple toxicities associated with the aging brain. Further experiments revealed that modulating activity of ATP synthase with J147 changes the levels of a number of other molecules-including levels of ATP itself-and leads to healthier, more stable mitochondria throughout aging and in disease. Link to comment Share on other sites More sharing options...
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