Gordo Posted February 17, 2018 Report Share Posted February 17, 2018 I think this is a very interesting emerging area of study, and there is now also a test you can take which may be useful for evaluating the effectiveness of various interventions. See: https://joshmitteldorf.scienceblog.com/2018/02/14/methylation-aging-clock-an-update/ Link to comment Share on other sites More sharing options...
TomBAvoider Posted February 18, 2018 Report Share Posted February 18, 2018 Thank you for this Gordo. Josh is an amazing guy... eons ago, when there was just the CR email list, Josh was briefly active, and always very interesting. His blog is an absolute treasure. The methylation age test seems intriguing, but I'd like a bit more color on it, as the report that I saw in the comments from one of the readers who took the test, seems somewhat confusing and underwhelming... in other words, the idea is absolutly fantastic, but the implementation in the test may not be ready for prime time just yet. I don't have the background to evaluate the technical merits of the test as it is implemented at the moment, but I'd love it if someone who is more qualified could chime in... MR? I'm going to follow this very closely, because if this checks out, I'd absolutely be onboard with getting tested (plus I'm chomping at the bit to try rapa). Thank you again, Gordo for bringing this up. Link to comment Share on other sites More sharing options...
mikeccolella Posted February 18, 2018 Report Share Posted February 18, 2018 “Speaking before Horvath at the same conference, Jim Watson claims there are many supplements and medications that can slow the Horvath clock. The one he focuses on is metformin, which, he says, has epigenetic effects via an entirely different pathway from lowering blood sugar (the purpose for which it has been prescribed to tens of millions of diabetics” Quoted from the mittledorf blog mentioned in this trhead. It looks more and more like we ALL SHOULD BE TAKING METFORMIN!!! My overweight long time former smoking father in law just turned 90. He is amazingly vital,vibrant. Incredibly so. He has been on metformin for 20 years and he eats a typical american junk diet and never ever exercised!!! Link to comment Share on other sites More sharing options...
mccoy Posted February 19, 2018 Report Share Posted February 19, 2018 It's interesting to observe all the mechanisms by which metformin underactivates mTOR, for example by AMPK activation and IGF-1→PIK3→Akt attenuation: Anti-tumor activity of metformin: from metabolic and epigenetic perspectives AFAIK, Met is considered a relatively safe but not usually powerful life prolonging drug, whereas rapamycine is considered a potentially unsafe, but very powerful one. An issue of risk optimization, or risk appetite as sometimes they like to define it. Link to comment Share on other sites More sharing options...
mccoy Posted February 19, 2018 Report Share Posted February 19, 2018 ...whereas the DNA methylation issue is something which I wasn't aware of Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver Personally, if not a diabetic, I would choose the safest option, the natural source of the molecule itself. galega officinalis Link to comment Share on other sites More sharing options...
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