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High salt intake hazards

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This paper found in als papers list would seem to agree with Dr Greger's assertions about the danger of salt intake.

I only read the abstract however, and the question remains? How much is high salt itnake (in humans and not mice?)


High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism.
Lanaspa MA, Kuwabara M, Andres-Hernando A, Li N, Cicerchi C, Jensen T, Orlicky DJ, Roncal-Jimenez CA, Ishimoto T, Nakagawa T, Rodriguez-Iturbe B, MacLean PS, Johnson RJ.
Proc Natl Acad Sci U S A. 2018 Mar 5. pii: 201713837. doi: 10.1073/pnas.1713837115. [Epub ahead of print]
PMID: 29507217
Dietary guidelines for obesity typically focus on three food groups (carbohydrates, fat, and protein) and caloric restriction. Intake of noncaloric nutrients, such as salt, are rarely discussed. However, recently high salt intake has been reported to predict the development of obesity and insulin resistance. The mechanism for this effect is unknown. Here we show that high intake of salt activates the aldose reductase-fructokinase pathway in the liver and hypothalamus, leading to endogenous fructose production with the development of leptin resistance and hyperphagia that cause obesity, insulin resistance, and fatty liver. A high-salt diet was also found to predict the development of diabetes and nonalcoholic fatty liver disease in a healthy population. These studies provide insights into the pathogenesis of obesity and diabetes and raise the potential for reduction in salt intake as an additional interventional approach for reducing the risk for developing obesity and metabolic syndrome.
NAFLD; fructose; metabolic syndrome; obesity; salt



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