TomBAvoider Posted June 5, 2018 Report Share Posted June 5, 2018 (edited) Thanks to Sibirak for posting this paper in the CR Science & Theory section in the thread "Associations of Body Mass Index and Waist Circumference with 3-Year All-Cause Mortality Among the Oldest Old" on 06/04/2018. I thought it was a consequential enough paper that it deserved its own thread, and I hereby re-post it for discussion and general edification. Some reasons why this paper is important: 1)Many of us are fans of sites like 23andme where we can browse our genetics for variants that might be informative from a health perspective. This paper makes it clear that just having our gene variants identified is of limited usefulness, because a "detrimental", or "protective" variant is so only conditionally, and it can reverse impact upon a variety of factors including age and interaction with other genes as well as the environment, lifestyle factors and medication. 2)Any number of studies showing benefits/harm of a diet, lifestyle choice or medication is highly dependent on your individual mix of genes, age and environment. What might be good advice for one person may be irrelevant or harmful to another 3)It makes clear that the current state of knowledge about how all these factors interact make a lot of dietary advice and interventions, basically random. 4)Your individual background is a key factor in your health and longevity Puzzling role of genetic risk factors in human longevity: “risk alleles” as pro-longevity variants Biogerontology. 2016; 17: 109–127. Published online 2015 Aug 26. doi: 10.1007/s10522-015-9600-1 PMCID: PMC4724477 NIHMSID: NIHMS718561 PMID: 26306600 Abstract Complex diseases are major contributors to human mortality in old age. Paradoxically, many genetic variants that have been associated with increased risks of such diseases are found in genomes of long-lived people, and do not seem to compromise longevity. Here we argue that trade-off-like and conditional effects of genes can play central role in this phenomenon and in determining longevity. Such effects may occur as result of: (i) antagonistic influence of gene on the development of different health disorders; (ii) change in the effect of gene on vulnerability to death with age (especially, from “bad” to “good”); (iii) gene–gene interaction; and (iv) gene–environment interaction, among other factors. A review of current knowledge provides many examples of genetic factors that may increase the risk of one disease but reduce chances of developing another serious health condition, or improve survival from it. Factors that may increase risk of a major disease but attenuate manifestation of physical senescence are also discussed. Overall, available evidence suggests that the influence of a genetic variant on longevity may be negative, neutral or positive, depending on a delicate balance of the detrimental and beneficial effects of such variant on multiple health and aging related traits. This balance may change with age, internal and external environments, and depend on genetic surrounding. We conclude that trade-off-like and conditional genetic effects are very common and may result in situations when a disease “risk allele” can also be a pro-longevity variant, depending on context. We emphasize importance of considering such effects in both aging research and disease prevention. Edited June 5, 2018 by TomBAvoider Quote Link to comment Share on other sites More sharing options...
Join the conversation
You can post now and register later. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.