Mccoy, a Google search for carbon sources that activate pro-growth pathways or carbon sources that activate pro-pro-aging pathways yielded some apparently relevant articles. I haven't had the time yet to delve into them.
Replicative and Chronological Aging in Saccharomyces cerevisiae
One issue surrounding studies of replicative aging in yeast involves the choice of growth conditions, which can have major effects on experimental outcome (see section on chronological life span below). For the vast majority of replicative aging studies, growth on rich medium in the presence of 2% glucose (YPD, Yeast Peptone Dextrose) is the method of choice. It is clear, however, that life span can be affected by these choices. For instance, lowering glucose concentration, a condition that is used to model dietary (or calorie) restriction in multicellular eukaryotes, causes life span extension in many, but not all, strain backgrounds. Alternate carbon sources have also been tested to a lesser extent. Budding yeast is a facultative anaerobe that generates most of its energy in the presence of ample glucose through fermentation, with only limited respiratory metabolism. Since most mammalian tissues rely primarily on respiration rather than fermentation, it has been argued that use of a respiratory carbon source such as glycerol may make for more relevant comparison to human aging (Botta et al., 2011). This assertion has yet to be rigorously evaluated. A relatively small number of studies have also examined RLS using synthetic defined (SD) medium, which is commonly used in the chronological life span assay (below), but a direct comparison of life span on SD versus YPD has not been performed. In summary, there is a need for a broader understanding for how different environmental factors, including the nutritional status of the growth medium, influence yeast RLS.
The article has many more references to carbon sources-- the quote is just an example. It's a dense article and I haven't digested it in the least.
Also Google carbon source substitution.
Tor1/Sch9-Regulated Carbon Source Substitution Is as Effective as Calorie Restriction in Life Span Extension
Min Wei ,Paola Fabrizio ,Federica Madia,Jia Hu,Huanying Ge,Lei M. Li,Valter D. Longo
Published: May 8, 2009
Abstract The effect of calorie restriction (CR) on life span extension, demonstrated in organisms ranging from yeast to mice, may involve the down-regulation of pathways, including Tor, Akt, and Ras. Here, we present data suggesting that yeast Tor1 and Sch9 (a homolog of the mammalian kinases Akt and S6K) is a central component of a network that controls a common set of genes implicated in a metabolic switch from the TCA cycle and respiration to glycolysis and glycerol biosynthesis. During chronological survival, mutants lacking SCH9 depleted extracellular ethanol and reduced stored lipids, but synthesized and released glycerol. Deletion of the glycerol biosynthesis genes GPD1, GPD2, or RHR2, among the most up-regulated in long-lived sch9Δ, tor1Δ, and ras2Δ mutants, was sufficient to reverse chronological life span extension in sch9Δ mutants, suggesting that glycerol production, in addition to the regulation of stress resistance systems, optimizes life span extension. Glycerol, unlike glucose or ethanol, did not adversely affect the life span extension induced by calorie restriction or starvation, suggesting that carbon source substitution may represent an alternative to calorie restriction as a strategy to delay aging.
Longo et al have an article in the book "Calorie Restriction, Longevity and Aging" (2010) where they briefly discuss glycerol and carbon source substitution (p.101-102), citing the above mentioned article.
In contrast with glucose and ethanol, presence of either carbon source promotes aging, glycerol not only does not shorten life span of DR-ed yeast, its uptake and utilization may contribute to long term survival (Wei et al., 2008). Taken together, the data suggest that genetically induced "carbon source substitution" of the pro-aging ethanol with the neutral glycerol in long-lived mutants creates a DR-like environment.
There are many articles to read! I await you thorough review and analysis.
Edited by Sibiriak, 12 June 2018 - 03:31 AM.