Jump to content

Riddled with mutations


corybroo
 Share

Recommended Posts

Medical News Today had an article about looking at the "healthy" tissue and the mutations therein.

Cancer: Even healthy tissue is 'riddled with mutations'     https://www.medicalnewstoday.com/articles/323392.php  Based on an article at http://science.sciencemag.org/content/early/2018/10/17/science.aau3879 that I do not have access to.

The researchers "sampled healthy tissue from the esophagi of nine individuals aged 20–75. None of these people had any history of esophageal cancer or other medical issues with that part of their body."

Next, they carried out whole-genome sequencing to map the presence of mutated cells in these healthy samples.  They found that, to their surprise, people in their 20s had hundreds of mutations in each cell. In older participants, this figure rose to more than 2,000 per cell

Mutations in some genes gave the cells a competitive advantage, meaning that, as they divided and conquered, they outcompeted cells without the mutation and colonized large patches of tissue; this created a patchwork of mutant cells.

I interpret this as being one of the reasons apoptosis (as generated by CR) is beneficial.   My *guess* is that apoptosis is likely to go after the most different cells first.

Cory

 

 

Link to comment
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

Loading...
 Share

×
×
  • Create New...