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200mg of trans-resveratrol equals howmany mg of resveratrol?


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Fernando Gabriel, I looked up the literature but apparently, resveratrol is found in its cis- or trans- isomer and the trans-  form is prevalent.

From the above, it would appear that commercial resveratrol = trans-resveratrol in lieu of other details.

 

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Biomedicines. 2018 Sep; 6(3): 91.
Published online 2018 Sep 9. doi: 10.3390/biomedicines6030091
PMCID: PMC6164842
PMID: 30205595

Resveratrol: A Double-Edged Sword in Health Benefits

 
 
Quote

7. Conclusions and Future Perspectives

Resveratrol is a nutraceutical belonging to stilbenoid group, widely distributed in the plant kingdom and with several therapeutic effects. Structurally, stilbenoids possess two aromatic rings linked by an ethylene or ethene bridge with a variety of substituents. Even though, the presence of double bond suggests that stilbenoids exist in cis- as well as trans-form. trans-form is more stable and with high bioactive effects. 

 

Edited by mccoy
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Interesting study, mccoy. Thanks.

A few things jumped out:

"Resveratrol antioxidant potential has been attributed to its ROS-scavenging capacity [112,113] and to an up regulation capacity on cells antioxidant defense [114]. Studies have reported that resveratrol could act as a signaling molecule within tissues and cells in modulating genes and proteins expression through redox-sensitive intracellular pathways activation. Thus, cell tolerance against oxidative environment could be attributed to gene expression changes and to a raise in antioxidant defense systems action and synthesis, which eventually results in cell survival and adaptation [115,116,117]. Moreover, depending on enzymatic reactions conditions, resveratrol can be (auto-)oxidized to generate semiquinones and relatively stable 4′-phenoxyl radical, finally leading to ROS production [118,119]. Such polyphenols’ oxidative reactions are influenced by pH and presence of hydroxyl anions or organic bases [120,121].

A study carried out by Martins et al. revealed that resveratrol can modulate different pathways at a time, which can result in distinct and even opposite biological effects, depending on its concentration or treatment time defined. The authors documented that, although a dose-dependent resveratrol pro-oxidative effect leads to cells oxidative stress over lesser time exposure, at same dose but with an increase in exposure time, less expressive cytotoxicity was found. This suggest that surviving cells seemed to be more resistant to resveratrol-induced damages, being its effects attenuated over treatment time [114]. Additionally, low resveratrol doses (0.1–1.0 μg/mL) has been documented to enhance cell proliferation, whereas higher doses (10.0–100.0 μg/mL) induces apoptosis (Figure 2) and decreases mitotic activity on human tumors and endothelial cells [122]. Recently, dual resveratrol pattern effects on HT-29 colon cancer cells death and proliferation were observed, where at low concentrations (1 and 10 μmol/L), resveratrol increased cells number, while at higher doses (50 or 100 μmol/L) resveratrol reduced cells number and increased apoptotic or necrotic cells percentage [123].

In a very interesting study, dose-time dependency of acute resveratrol administration on lipoperoxidation levels (in heart, liver and kidney of male rats synchronized with a 12-h dark-light cycle) was investigated. It was documented that resveratrol behaved as an antioxidant during dark span and as a pro-oxidant during light span, possibly reflecting the putative changing ratio between pro- and antioxidant activities in various organs during 24-h cycle or postprandial oxidative burst that occurred after a meal [124]. There is an interesting correlation among dietary polyphenols pro-oxidant and cytotoxic activities, such as to resveratrol. In fact, since every antioxidant is a redox agent it might become a pro-oxidant, accelerating lipid peroxidation and/or inducing DNA damages under special conditions. In this way, it has been proposed that such pro-oxidant action could be an important mechanism of action to resveratrol anti-cancer and apoptotic-inducing properties [112]. It has already been reported that resveratrol can lead to DNA damages, as well as to a reversible or irreversible cell cycle interruption mediated by its pro-oxidant effect [117]. "

 

I have not taken resveratrol supplements in a while, but since I have been reading that it may enhance intermittent fasting triggered autophagy, I just ordered some. I'll take about 1400mg on and off every three months, as it seems to me it would be beneficial.

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