TomBAvoider Posted September 6, 2019 Report Share Posted September 6, 2019 I guess it stands to reason, but it's still a bit of a jolt to fully appreciate the fact that pharmaceuticals/medication interacts with diet and can be profoundly influenced in its effectiveness to the point of total ineffectiveness. This appears to be true of metformin as well. The following study was initially in fruit flies, but then an attempt has been made to validate those findings in humans. Bottom line, it's possible that if you are on a high carb diet - or just have a lot of sugar in your diet - that your gut biome can cause metformin to become ineffective. In other words, it's possible that to obtain any benefits from metformin, your diet must have a particular profile. Obviously, while this particular case applies to metformin, doesn't it stand to reason that it's true for many other drugs/interventions? They may all interact with other medications, diet, lifestyle choices and genetics. So, perhaps some of the variability of outcomes might be down to these confounders. Say, if you take rapa, perhaps there are things you should/should not do to derive any benefits. Perhaps another reason to carefully evaluate the individual and their entire profile before prescribing any drug/intervention - again more toward individualized medicine. Here's the study in question: https://www.sciencedaily.com/releases/2019/08/190830112810.htm "Implications for metformin treatment "Our results shed light on how the complex network of interactions between diet, microbiota and host impacts the efficacy of drugs," says Cabreiro. "With our high-throughput screening approach we now finally have a tool at hand that allows us to tackle this complexity." The findings of this study may help to inform dietary guidelines or the development of genetically engineered bacteria that could be used to enhance the beneficial effects of metformin. They may also provide a valuable insight into the evidence that suggests that metformin-treated type-2 diabetic patients are healthier and live longer than non-diabetic individuals." Quote Link to comment Share on other sites More sharing options...
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