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mccoy

Resveratrol latest tips from sinclair

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I've listened to the latest podcast of Rhonda Patrick with Dave Sinclair (has it been posted anywhere else? I'm not aware of it ).

I found this one maybe a little different from the others. Among the others, one very useful tip is the fact that resveratrol powder is very susceptible to light and heat and degrades in warm temperatures and in the presence of humidity. This made me ruminate... The supplement goes from the production facility to the warehouse/distributor's shelf. How long does it remain on the shelves? In which temperatures? With which likelihood it starts to degrade? Then it hits our homes. How long do we keep it and in which conditions?

Considering that resveratrol should be kept in the freezer or fridge just after manufacturing, it's easy to understand that in many cases it constitutes just a placebo when it is ingested by the final consumer.

Beyond that, it's interesting to hear yet again about NAD, NMN, NR.... If I'm not wrong Sinclair ceased to be involved into supplements development and is into drugs development (NMN is an example, but I didn't know that it is a prescription drug).

 

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Is anyone here taking resveratrol??

 I know Ron indicated before Christmas in his supplement thread that he was.

 I am curious to know your rationale for taking and what you are taking (dose, type/brand ).

 I am considering taking a small amount (100mg per day) trans resveratrol Doctors Best brand which includes some other polyphenols.

 I understand it blunts some of the positive effects of HIIT and other forms of exercise; however I (sadly/honestly) do zero HIIT these days or exercise other than resistance training and also don’t even follow what one would consider CR.  
I don’t over eat, stay lean , practice TRF and think that there may be some cardiovascular, insulin sensitivity, autophagy benefits to be had given my diet and lifestyle.

150mg per day had impressive results in obese men.

Thanks for comments,

Clinton

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If you are on a calorie restriction site why don't you practice CR? How many calories do you consume, what are your lipid parameters, what is your blood pressure and other blood tests?
BMI 22 is not the best we have this impression because centenarians are generally low (4 feet and 11 inches on average) and consumes a lower number of calories which gives this impression, but high centenarians have a lower BMI generally as is the case Walter Breuning who was 5 feet 8 inches and had a BMI 19

If you are on a calorie restriction site why don't you practice CR? How many calories do you consume, what are your lipid parameters, what is your blood pressure and other blood tests?
BMI 22 is not the best we have this impression because centenarians are generally low (4 feet and 11 inches on average) and consumes a lower number of calories which gives this impression, but high centenarians have a lower BMI generally as is the case Walter Breuning who was 5 feet 8 inches and had a BMI 19
If you want to leave the weight training aside and after you stop losing muscle, lower the fat percentage to 5-10% and then keep it for a while and then do the blood test.

Edited by Fernando Gabriel

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Gents,

I was hoping for feedback other than the above 'post' & interested in any comments,

Thank you,

Clinton

Edited by Clinton

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1 hour ago, Fernando Gabriel said:

If you are on a calorie restriction site why don't you practice CR?

Fernando,

I ask that you please do not respond to any of my posts,

Clinton

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Clinton, I considered taking resveratrol but haven't seen compelling evidence of benefits to justify the cost.   I think it is slightly more compelling for those with metabolic syndrome but I haven't seen much to suggest benefits for those already well engaged in exercise and diet optimization with CR and/or fasting.  I'd reconsider if someone here made a good case for it with links to large RCTs showing substantial benefits additive to other healthy lifestyle factors.

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Clionton, I've listened to many podcasts featuring Dr. Sinclair but at the end I decided I won't take resveratrol for now. 

My suggestion would be that you try it out and report here in a few months.

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