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aging protein waves in blood

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Scientists Find Surprising Age-Related Protein Waves In Blood

https://www.npr.org/sections/health-shots/2019/12/05/785065299/scientists-find-surprising-age-related-protein-waves-in-blood

I thought aging was a linear process.  The above article reports finding three distinct waves of change.  First wave in 30s, second around 60, and third around 80.

One hope is to develop a personalized aging clock.

"With this flood of new data about blood proteins, it's a daunting task to figure out whether each one causes aging, slows it down or is merely a result of the aging process."

This research "is really the first step in categorizing and cataloging the age-related biomarkers," 
 

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The paper is in PubMed this morning:

Undulating changes in human plasma proteome profiles across the lifespan.
Lehallier B, Gate D, Schaum N, Nanasi T, Lee SE, Yousef H, Moran Losada P, Berdnik D, Keller A, Verghese J, Sathyan S, Franceschi C, Milman S, Barzilai N, Wyss-Coray T.
Nat Med. 2019 Dec;25(12):1843-1850. doi: 10.1038/s41591-019-0673-2. Epub 2019 Dec 5.
PMID: 31806903
https://www.biorxiv.org/content/biorxiv/early/2019/09/01/751115.full.pdf
Abstract
Aging is a predominant risk factor for several chronic diseases that limit healthspan1. Mechanisms of aging are thus increasingly recognized as potential therapeutic targets. Blood from young mice reverses aspects of aging and disease across multiple tissues2-10, which supports a hypothesis that age-related molecular changes in blood could provide new insights into age-related disease biology. We measured 2,925 plasma proteins from 4,263 young adults to nonagenarians (18-95 years old) and developed a new bioinformatics approach that uncovered marked non-linear alterations in the human plasma proteome with age. Waves of changes in the proteome in the fourth, seventh and eighth decades of life reflected distinct biological pathways and revealed differential associations with the genome and proteome of age-related diseases and phenotypic traits. This new approach to the study of aging led to the identification of unexpected signatures and pathways that might offer potential targets for age-related diseases.

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