InquilineKea Posted June 1, 2020 Report Share Posted June 1, 2020 (edited) I got mine from https://www.unitedpharmacies.md/search.html?search_text=metformin&searchbutton= . https://www.alldaychemist.com/diabetes.html is another source but now it turns out that the bottle i got (apotex) has 3.8x the maximum acceptable dose of the carcinogen NDMA... https://www.valisure.com/wp-content/uploads/Valisure-FDA-Citizen-Petition-on-Metformin-v3.9.pdf Edited June 1, 2020 by InquilineKea Quote Link to comment Share on other sites More sharing options...
Gordo Posted June 1, 2020 Report Share Posted June 1, 2020 (edited) Unless you are diabetic, taking metformin is probably a bad idea (and not just because of possible trace carcinogens). Do more reading. Edited June 2, 2020 by Gordo Quote Link to comment Share on other sites More sharing options...
Saul Posted June 1, 2020 Report Share Posted June 1, 2020 Good advice. -- Saul Quote Link to comment Share on other sites More sharing options...
InquilineKea Posted June 2, 2020 Author Report Share Posted June 2, 2020 It's complicated. Metformin may not increase maximum lifespan (as ITP data shows), and Kaeberlein isn't excited about it, but still, the effects on healthspan are still important. But still.. https://pubmed.ncbi.nlm.nih.gov/29457866/ It could be that berberine is more effective in general, but it's still weaker. Quote Link to comment Share on other sites More sharing options...
mccoy Posted June 2, 2020 Report Share Posted June 2, 2020 Since when I read about the nausea problems and the negative effects on muscle protein synthesis I definitely buried the idea of taking metformin... Quote Link to comment Share on other sites More sharing options...
Sibiriak Posted June 2, 2020 Report Share Posted June 2, 2020 (edited) 3 hours ago, InquilineKea said: ...the effects on healthspan are still important. The effects on health span are very unclear. From the article you linked: Quote ...metformin...potentially, may protect against cancer, cardiovascular disease, cognitive decline and aging. The expression levels of numerous microRNAs are also reportedly influenced by metformin treatment and may confer antidiabetic and anticancer activities. However, as the reported effects of metformin on epigenetic enzymes act to both increase and decrease histone acetylation, histone and DNA methylation, and gene expression, a significant degree of uncertainty exists concerning the overall effect of metformin on the epigenome, on gene expression, and on the subsequent effect on the health of metformin users. I agree with Gordo, Saul, and McCoy. We don't know much about the benefits of long term use of metformin by healthy individuals, and the risk of negative side effects is substantial. Resident skeptic and hype-buster TomBAvoider has nevertheless chosen to take metformin (driven by despair of growing old); you might want to look at some of his posts on the subject. For example, see the discussion here: Metformin linked to higher risk of Alzheimer's and Parkinson's Quote The risks are considerable - as I keep outlining, including in this thread wrt. metformin - but I am willing to take those risks for a fairly small chance of a gain. Simply resigning myself to doing nothing goes against my nature. It is psychologically easier - for me - to exert a degree of control, even if it's down to not very good odds; at least I can say "I elected to gamble". also: https://www.crsociety.org/topic/17114-metformin-and-growth-hormone-reverse-aging-in-humans/?page=2&tab=comments#comment-32996 https://www.crsociety.org/topic/17040-ampk-activates-mtorc2/?tab=comments#comment-31753 https://www.crsociety.org/topic/16940-metformin-and-longevity/?tab=comments#comment-30477 https://www.crsociety.org/topic/17040-ampk-activates-mtorc2/?tab=comments#comment-31738 https://www.crsociety.org/topic/16940-metformin-and-longevity/?tab=comments#comment-30476 https://www.crsociety.org/topic/16940-metformin-and-longevity/?tab=comments#comment-30483 Edited June 2, 2020 by Sibiriak Quote Link to comment Share on other sites More sharing options...
InquilineKea Posted June 4, 2020 Author Report Share Posted June 4, 2020 (edited) B12 is thought to be the association between metformin and Alzheimer's? Also metformin is thought to work synergistically with rapamycin. It lowers free fatty acids (which rapa increases) Edited June 4, 2020 by InquilineKea Quote Link to comment Share on other sites More sharing options...
InquilineKea Posted June 4, 2020 Author Report Share Posted June 4, 2020 Singapore - https://www.channelnewsasia.com/news/world/tests-show-carcinogen-in-diabetes-drug-metformin-online-pharmacy-12493048 all but 3 brands tested negative - i'd like to figure out what the other 43 are even with the positive-testing NDMA, the additional risks aren't high Quote Link to comment Share on other sites More sharing options...
drewab Posted June 4, 2020 Report Share Posted June 4, 2020 To answer your question on 'where do you source your metformin?' The answer is I don't and wouldn't do it without being under the supervision of a physician. Quote Link to comment Share on other sites More sharing options...
InquilineKea Posted June 4, 2020 Author Report Share Posted June 4, 2020 If you look at Rinton's FAQ, met + rapa had 23% increase, while rapa alone had like 13% Quote Link to comment Share on other sites More sharing options...
mccoy Posted June 5, 2020 Report Share Posted June 5, 2020 Watch out for some long-release metformin drugs Quote The US FDA is recommending a voluntary recall of certain extended release versions of metformin after testing revealed excessive levels of NDMA in some of these products. Metformin is the most commonly prescribed drug to treat type 2 diabetes. The NDMA contaminant has the potential to be carcinogenic if there is exposure to above acceptable levels over long term use. This recall does not apply to immediate release metformin products, and the agency recommends that clinicians continue to prescribe metformin when clinically appropriate. The FDA is contacting 5 pharmaceutical firms in particular as posted on the agency’s website, and is recommending that the companies voluntarily recall these products one of which listed on the agency’s site is Apotex Corp and its metformin hydrochloride ER USP 500 mg tablets.The FDA has become aware of NDMA in some metformin products in other countries which inspired them to test American supplies of metformin to determine the risk as part of an ongoing investigations into nitrosamine impurities across a variety of medication types, which includes recalls of hypertension and heartburn medications within the past 2 years. Quote Link to comment Share on other sites More sharing options...
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