Mike41 Posted August 20, 2020 Report Share Posted August 20, 2020 (edited) again we see lowest levels of ldl 84mg/dL we’re significantly associated with HIGHER mortality compared to men with moderately high levels of 117/ 137. The lower risk was about 40% if I’m reading this correctly. Thank you Al Pater for another study indicating that In males lower ldl may not be a goal we should be striving for. Personally my ldl is 105 but that Is with using 40 mg of Crestor. 020 Aug 16;10(8):e036976. doi: 10.1136/bmjopen-2020-036976.PMID: 32801200https://bmjopen.bmj.com/content/bmjopen/10/8/e036976.full.pdfAbstractObjectives: To investigate the relationship between low-density lipoprotein cholesterol (LDL-C) and all-cause mortality among middle-aged and elderly Chinese population.Design: Prospective cohort study.Setting: This study used data from the China Health and Retirement Longitudinal Study.Participants: Middle-aged and elderly participants with complete data were enrolled for a 4-year follow-up of total mortality and plasma levels of LDL-C, including 4981 male respondents and 5529 female respondents.Results: During a 4-year follow-up, there were 305 and 219 deaths in men and women, respectively. Compared with the first quintile (Q1) of LDL-C, the adjusted HRs (95% CIs) were 0.818 (0.531 to 1.260) for Q2, 0.782 (0.507 to 1.208) for Q3, 0.605 (0.381 to 0.962) for Q4 and 0.803 (0.506 to 1.274) for Q5 in men. The results from restricted cubic spine (RCS) showed that when the 20th percentile of LDL-C levels (84 mg/dL) was used as the reference, a lower LDL-C concentration (<84 mg/dL) was associated with a higher 4-year all-cause mortality risk. By contrast, both quintile analysis and RCS analysis did not show a statistically significant association in women.Conclusions: Compared with moderately elevated LDL-C (eg, 117-137 mg/dL), a lower plasma level of LDL-C (eg, ≤84 mg/dL) was associated with an increased risk of 4-year all-cause mortality in middle-aged and elderly Chinese men. The results suggest the potential harmful effect of a quite low level of LDL-C on total mortality.Keywords: epidemiology; preventive medicine; public health; risk management Edited August 20, 2020 by Mike41 Quote Link to comment Share on other sites More sharing options...
Join the conversation
You can post now and register later. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.