Jump to content

CpGs and longevity


Recommended Posts

Researchers offer insights into aging


a significant part of epigenetic aging occurs in regions with CpGs. A CpG is a region of DNA where the chemical elements cytosine and guanine are connected by a phosphate bond.

"CpGs are important because DNA methylation occurs in the area,"

 double-stranded breaks frequently occur in the genome [and] are efficiently repaired by proteins and enzymes known as chromatin modifiers.

According to the study, the chromatin modifiers leave the CpG Island to repair the breaks, and when they relocate, changes occur that alter gene expression and thus a cell's fate.

if [the chromatin modifiers] leave the island to perform a rescue, the island becomes compromised and vulnerable if all of them don't return.

species with longer life spans such as humans, alligators and elephants have higher levels of CpGs than species like fish and rodents

Link to comment
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.

Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

  • Create New...