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meat/dairy molecular link to cancer risk

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Researchers discover molecular link between diet and risk of cancer

An international team of researchers has identified a direct molecular link between meat and dairy diets and the development of antibodies in the blood that increase the chances of developing cancer.

Neu5Gc is a sugar molecule found in the tissues of mammals but not in poultry or fish. Humans develop antibodies to Neu5Gc in infancy, when they are first exposed to dairy and meat products.

team members measured the amount of Neu5Gc sugar in a variety of dairy and meat foods common in the French diet and calculated the daily Neu5Gc intake of 19,621 adults

"We found a significant correlation between high consumption of Neu5Gc from red meat and cheeses and increased development of those antibodies that heighten the risk of cancer," Dr. Padler-Karavani says.

this combination of methods allowed the researchers to predict that those who eat a lot of red meat and cheese will develop high levels and a different variety of the antibodies, and therefore may be at higher risk for cancer—especially colorectal cancer, but other cancers as well.

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The hypothesized linkage of consumption of mammalian meat and dairy to cancer via Neu5Gc has been around for a while.  But where is the evidence of Neu5Gc antibodies causing cancer?  Here is a study suggesting there is no such effect for colon cancer the variety of cancer of most concern for meat consumers in epidemiological studies.

No Increase in Colon Cancer Risk Following Induction with Neu5Gc-Bearing Rabbit Anti-T Cell IgG (ATG) in Recipients of Kidney Transplants


Based on data from 173,960 and 38,505 patients without and with ATG induction, respectively, we found no evidence that exposure to higher levels of anti-Neu5Gc is associated with a higher incidence of colon carcinoma.


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MMMmmm....., from the table below, goat's cheese has more Neu5Gc than bison's meat. But IARC recognizes bison and all other red (mammalian) meats as carcinogenic, whereas cheese and milk are not. So something does not add up, and maybe Neu5Gc is not really the source of carcinogenicity in mammalian flesh...

source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299224/


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