Jump to content
Mike Lustgarten

LDL: What's Optimal For Health And Longevity?

Recommended Posts

Amla Experiment Results

Results from my wife's 90-day experiment with taking an Amla supplement for her moderately high cholesterol are in. She religiously took two capsules per day (morning and evening) and didn't change her quite-healthy, near-vegan diet or exercise pattern.

Here are her LDL and HDL levels for the last few years, with the last two from May 2021 (pre-amla) and yesterday (post-amla) :

LDL: 130, 133, 133, 126, 116
HDL
: 067, 076, 071, 071, 074

Overall we were pleasantly surprised. An apparent drop in LDL of 10-15 mg/dL compared with where it has been consistently for the last few years, along with perhaps a slight increase in HDL after taking an inexpensive amla supplement for three months seems pretty good.

Her LDL is still on the high side, but we've decided to continue with the amla rather than considering a statin for now. We'll reevaluate her cholesterol level in a year.

--Dean

Share this post


Link to post
Share on other sites

I am glad your wife's results are moving in the right direction. But I'd be curious if the trend continues.

My LDL dropped from close to 100 to the 60s after I stopped consuming EVOO at home (still do when out in an Italian restaurant).  It has stayed there. I started taking about 2-3 grams of amla with my meals almost every day over the last half a year or more and have noticed no significant changes.

I believe that you consume a fair amount of EVOO and perhaps your wife does as well. You might want to experiment with cutting out EVOO and other oils at home and see what the effect is.

Share this post


Link to post
Share on other sites
5 hours ago, Ron Put said:

I believe that you consume a fair amount of EVOO and perhaps your wife does as well. You might want to experiment with cutting out EVOO and other oils at home and see what the effect is

Neither of us consume oils, extra virgin or otherwise. 

--Dean 

Share this post


Link to post
Share on other sites

Maybe a bit off-topic but related IMO.   I am looking for data supporting that the upper limit of 200mg/dL TC recommendation might be still too high.   The argument was about 1/3 of people who had a infarction also had their TC between 150-200.   But the disease was almost inexistent for those with a TC less than 150.  I remember having seen that more than 5 years ago, but for a reason I can't put my finger on it.    Or maybe it wasn't  founded.

Share this post


Link to post
Share on other sites

Yet another study finding low LDL is deadly:

Low density lipoprotein cholesterol and all-cause mortality rate: findings from a study on Japanese community-dwelling persons

Quote

Compared with individuals with LDL-C levels of 144 mg/dL or higher, the multivariable-adjusted Hazard ratio (and 95% confidence interval) for all-cause mortality was 2.54 (1.58–4.07) for those with LDL-C levels below 70 mg/dL, 1.71 (1.15–2.54) for those with LDL-C levels between 70 mg/dL and 92 mg/dL, and 1.21 (0.87–1.68) for those with LDL-C levels between 93 mg/dL and 143 mg/dL.

 

Share this post


Link to post
Share on other sites
19 hours ago, Todd Allen said:

Yet another study finding low LDL is deadly

Hm, looking at the second table, the low LDLs are also more likely to have hypertriglyceridemia and hyperuricemia. I'd also be curious if they are insulin resistant.

See this:

High triglycerides, low HDL cholesterol and a low LDL cholesterol per apolipoprotein b ratio predict incident diabetes in patients with established coronary artery disease

Share this post


Link to post
Share on other sites
13 hours ago, Ron Put said:

Hm, looking at the second table, the low LDLs are also more likely to have hypertriglyceridemia and hyperuricemia. I'd also be curious if they are insulin resistant.

Yes, I think context is everything.  Statistical findings for any given biomarker across a cohort or population may not hold for a different cohort.   Looking at very different cohorts producing very different results is desirable.

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

×