Jump to content

sugary diet endangers waste-eating protein P62


Recommended Posts

Study suggests sugary diet endangers waste-eating protein crucial to cellular repair

A protein that functions like the vintage video game Pac-Man, eating toxic cellular waste caused by high sugar intake, is itself compromised by a sugary diet

The protein alleviates age-related cellular damage stemming from too much sugar consumption

A high-sugar diet, typical in the United States, causes damaging byproducts to build up in cells. The byproducts, called advanced glycation end products (AGEs), accumulate and are linked with age-related diseases. [I’ve yet to meet anyone who thinks he/she is not on a low sugar, healthy diet.]

  • p62's (the Pac-Man-like protein) self-cleaning ability plays a role in clearance of AGEs. Augmenting p62 accelerates cell cleaning.
  • Loss of p62 leads to cell toxicity from sugar and accumulation of AGEs.
  • p62's targeting of cells for clean-up is compromised by glycative stress, a reaction from sugar.
  • Autophagy (the body's cell-cleaning process), when chemically enhanced, protects against glycative damage.


Link to comment
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.

Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

  • Create New...