Todd Allen Posted January 21, 2021 Report Share Posted January 21, 2021 Dietary Protein Deficit and Deregulated Autophagy: A New Clinico-diagnostic Perspective in Pathogenesis of Early Aging, Skin, and Hair Disorders Table 7 Various HCLP (high-carb low-protein) syndromes and their associated dermatological and medical presentations Syndrome complex Dermatological presentation Medical presentation HCLP syndrome 1 Usually follow a diet high on carbs and fats Adolescents and young adults Acne Hirsutism Telogen effluvium Seborrhea Perioral pigmentation Periorbital pigmentation Prematureandrogenetic alopecia Post-inflammatory hyperpigmentation Perioral/periorbital pigmentation Acanthosis nigricans Seborrhea Weight gain Irregular cycles Polycysticovarian syndrome (PCOS) Hormonal disturbances Gynecomastia Delayed secondary facial hair in males HCLP syndrome 2 Usually missing breakfast or late breakfast/prolonged starvation Commonly seen in middle-aged females and night shift workers Melasma Macular amyloidosis Striae Periorbital pigmentation Perioral pigmentation, oral aphthous ulcers Vitiligo, Urticaria Alopecia areata Lichen planus Telogen effluvium Hypothyroidism Vitamin D deficiency Vitamin B12 deficiency Deficient iron studies Autoimmune disorders HCLP syndrome 3 Usually follow a diet high on carbs and fats More common in middle-aged or elderly men or peri-menopausal females Psoriasis vulgaris Androgenetic alopecia without genetic predisposition Female pattern hair loss Periorbital pigmentation and tear trough formation Acanthosis nigricans Macular amyloidosis Truncal obesity Skin tags Hypertension Type 2 diabetes Hyperinsulinemia Coronary artery disease Obesity Dyslipidemia Hyperuricemia Homocysteinemia Quote Link to comment Share on other sites More sharing options...
Sibiriak Posted January 21, 2021 Report Share Posted January 21, 2021 (edited) Quote Protein deficiency was encountered in most of the patients reporting to our clinic, most of them taking not even half of the required daily intake (<30 g/day) and more than one-fourth were very poor eaters (<20 g/day). Quote All our patients showing aging were deficient in protein intakes, resulting in a compromise in collagen and elastin synthesis and efficiency of enzymes like matrixmetalloproteinases (MMPs) which help in degradation of old proteins Table 3 Protein intake groups according to daily intake Protein intake (g/day) No. of subjects (n) Percentage 10-30 (severe deficiency/poor intake) 67 68.36 30-50 (moderate deficiency/low intake) 23 23.47 ≥50 (no deficiency/optimal intake) 8 8.16 Total Edited January 21, 2021 by Sibiriak Quote Link to comment Share on other sites More sharing options...
mccoy Posted January 21, 2021 Report Share Posted January 21, 2021 I was wondering how it is possible to eat so few protein in the Western world, but then I saw the study was carried out in India, with prevalently anorexic (or very low income) individuals. It would have been interesting to have the units in g/kg/d, so that a comparison with the accepted RDA would have been possible. Quote Link to comment Share on other sites More sharing options...
Todd Allen Posted January 21, 2021 Author Report Share Posted January 21, 2021 6 hours ago, mccoy said: I was wondering how it is possible to eat so few protein in the Western world, but then I saw the study was carried out in India, with prevalently anorexic (or very low income) individuals. From the paper: Quote Discussion The Indian diet system has the advantage that most of the food cooked is fresh and free of preservatives, but the downside is lack of awareness of the actual food value. Our textbooks do not highlight the problems faced due to protein deficiency; as most of the literature we follow is written by western population who usually consumes protein-rich diet and face less problems like psoriasis, diabetes, dyslipidemias, and other metabolic syndromes than we do. ... Protein deficiency was encountered in most of the patients reporting to our clinic, most of them taking not even half of the required daily intake (<30 g/day) and more than one-fourth were very poor eaters (<20 g/day). Surprisingly the population visiting the clinic is affluent and easily affording various treatments. The dietary deficiency was mostly due to lack of awareness about the quality of food, busy job profiles, faulty lifestyle, or crash dieting for quick weight loss. Quote Link to comment Share on other sites More sharing options...
mccoy Posted January 21, 2021 Report Share Posted January 21, 2021 Incredible... But statistically likely in a country with 1.3 billion citizens. Quote Link to comment Share on other sites More sharing options...
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