Todd Allen Posted February 2, 2021 Report Share Posted February 2, 2021 Want to impress others with your low cholesterol? Then test it in the afternoon: https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12547 Quote The biological clock, whose function deteriorates with increasing age, determines bodily circadian (i.e. 24h) rhythms, including that of cholesterol metabolism. Dampening of circadian rhythms has been associated with aging and disease. Therefore, we hypothesized that individuals with a familial predisposition for longevity have a higher amplitude circadian serum cholesterol concentration rhythm. The aim of this study was to investigate circadian rhythmicity of serum cholesterol concentrations in offspring of nonagenarian siblings and their partners. ... We conclude that familial longevity is characterized by a high circadian rhythmicity of non‐HDL‐C in healthy elderly offspring from nonagenarian siblings. Quote Link to comment Share on other sites More sharing options...
Mike Lustgarten Posted February 3, 2021 Report Share Posted February 3, 2021 Interesting data. So much of biomarker testing involves fasted and in the morning, but considering alterations for circulating biomarkers at other times of the day is dramatically understudied. Quote Link to comment Share on other sites More sharing options...
Ron Put Posted February 5, 2021 Report Share Posted February 5, 2021 I guess we discover more complexity the more we learn. The opposite is true for blood pressure if I recall: High BP amplitude throughout the day does not bode well for one's longevity. Quote Link to comment Share on other sites More sharing options...
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