aducknamedjoe Posted April 16, 2021 Report Share Posted April 16, 2021 I'm putting together an overview of CR and was wondering what folks here consider the most important/convincing research that's foundational to the idea and practice of caloric restriction? I'm assuming CALERIE, the Minnesota Starvation Experiment, and the NIA and WNPRC rhesus monkey studies feature highly, but what else? Here's a list of some I've already collected: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674854/#R2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125200/ http://www.wealthandhealth.ltd.uk/over100/C.%20M.%20McCAY%201935.pdf https://pubmed.ncbi.nlm.nih.gov/15885745/ https://pubmed.ncbi.nlm.nih.gov/11991408/ dogs https://www.livescience.com/3725-methuselah-mouse-rejuvenation-prize-awarded.html https://www.nature.com/articles/nature11432 negative monkey finding but some positive health results https://www.nih.gov/news-events/news-releases/nih-study-finds-calorie-restriction-does-not-affect-survival https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812811/ positive monkey finding https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247583/ positive monkey finding https://pubmed.ncbi.nlm.nih.gov/12634286/ older positive monkey finding https://www.thelancet.com/journals/landia/article/PIIS2213-8587(19)30151-2/fulltext Humans CALERIE https://en.wikipedia.org/wiki/Minnesota_Starvation_Experiment https://pubmed.ncbi.nlm.nih.gov/26399868/ Quote Link to comment Share on other sites More sharing options...
Saul Posted April 16, 2021 Report Share Posted April 16, 2021 the best monkey study is Luigi Fontana's two studies of those of us who volunteered for his study. There are two papers about the study: the first paper in in the PNAS, the second is in some journal of Cardiology. you can probably find links in the CR Society home page. -- Saul Quote Link to comment Share on other sites More sharing options...
Matt Posted April 17, 2021 Report Share Posted April 17, 2021 (edited) I wouldn't call the CALERIE studies that informative for the effects of serious life-extending CR. They were more like weight loss studies and not nearly as restricted as people who took part in the Fontana studies. However, there are other positives of the CALERIE study in that they were randomized and not a self selected group. Rather than the starvation experiment, you might want to look up Biosphere 2 instead. 🙂 There is a free PDF available https://academic.oup.com/biomedgerontology/article/57/6/B211/564317 You can check out my article on CR here: http://www.crvitality.com/benefits-of-calorie-restriction/ There's a bunch of references you can look up at the bottom. Hope that helps! I'll check through the links you posted later... Edited April 17, 2021 by Matt Quote Link to comment Share on other sites More sharing options...
aducknamedjoe Posted April 17, 2021 Author Report Share Posted April 17, 2021 Awesome, super helpful, thank you both! Quote Link to comment Share on other sites More sharing options...
aducknamedjoe Posted April 19, 2021 Author Report Share Posted April 19, 2021 FYI, here's the published overview: https://www.longevityadvice.com/caloric-restriction/ I added in Fontana's studies plus the Biosphere 2 experiment, and @Matt I also linked your guide towards the end in the "how to start" section, thank you! Quote Link to comment Share on other sites More sharing options...
Saul Posted April 19, 2021 Report Share Posted April 19, 2021 😀 Quote Link to comment Share on other sites More sharing options...
Saul Posted April 20, 2021 Report Share Posted April 20, 2021 Also, there's a short book written recently by Luigi that's available form Amazon -- I bought it in Kindle format. IMO, it's the best book on the subject. -- Saul Quote Link to comment Share on other sites More sharing options...
Matt Posted April 22, 2021 Report Share Posted April 22, 2021 (edited) On 4/19/2021 at 7:00 PM, aducknamedjoe said: FYI, here's the published overview: https://www.longevityadvice.com/caloric-restriction/ I added in Fontana's studies plus the Biosphere 2 experiment, and @Matt I also linked your guide towards the end in the "how to start" section, thank you! @aducknamedjoe Thanks JP! I'll read your article when I get a chance later today. 🙂 Edited April 22, 2021 by Matt Quote Link to comment Share on other sites More sharing options...
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