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Mike Lustgarten, May 30 in General Health and Longevity
so does starvation reduce fgf21? obese animals have loads of it and are often resistant
also it seems like you need fat reserves for this to have tissue to work on?
Why would you expect to need fat reserves for the FGF21 effect? In the FGF21 TG mice, body composition wasn't different when compared with WT (see Fig 1):https://elifesciences.org/articles/00065
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