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Insulin Sensitivity Is A Hallmark Of Longevity

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Papers referenced in the video:

Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice https://pubmed.ncbi.nlm.nih.gov/24175...

Glucose regulation and oxidative stress in healthy centenarians https://pubmed.ncbi.nlm.nih.gov/12543...

Distribution of blood glucose and prevalence of diabetes among centenarians and oldest-old in China: based on the China Hainan Centenarian Cohort Study and China Hainan Oldest-old Cohort Study https://pubmed.ncbi.nlm.nih.gov/32643...

Prevalence and Ethnic Pattern of Diabetes and Prediabetes in China in 2013 https://pubmed.ncbi.nlm.nih.gov/28655...

Families enriched for exceptional longevity also have increased health-span: findings from the long life family study https://pubmed.ncbi.nlm.nih.gov/24350...

HOMA calculator: https://www.omnicalculator.com/health...

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Edited by Mike Lustgarten
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1 hour ago, Ron Put said:

But what if both insulin and glucose go up, yet HOMA is normal?

HOMA-IR is a calculated value based on fasted insulin and blood glucose.  I think it is just multiplying them together with a constant.  It is considered a mediocre estimate of insulin resistance used mainly because it is easy to do.

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20 hours ago, Ron Put said:

But what if both insulin and glucose go up, yet HOMA is normal?

If both go up, then HOMA-IR should increase as well, the greater the HOMA-IR, the greater the insulin resistance, wrong direction as Mike says (and as Todd wrote, it's not a very reliable parameter).

Edited by mccoy
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I disagree that it's not reliable-glucose and insulin are direct measures, it's practical to measure them while fasting, and accordingly, there should be minimal variability, and hence reliable if done fasted. Other measures of insulin sensitivity are usually done in the fed state (OGTT, ITT), but there may be more variability when eating real food especially considering that the OGTT involves drinking a bolus of sugar.

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  • 2 weeks later...

Impressive.    I don''t understand how the KO mice were conditioned.   In the video it says; "growth releasing hormone was knocked out" by the removal of a protein responsible for growth hormone.    How was it done?  What protein?  I see a reference to "Nfe2l2 protein, mouse".   Any equivalent for humans?

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