Mike Lustgarten Posted June 21, 2021 Report Share Posted June 21, 2021 (edited) https://www.youtube.com/watch?v=jyOGvKe1e1Y Papers referenced in the video: Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice https://pubmed.ncbi.nlm.nih.gov/24175... Glucose regulation and oxidative stress in healthy centenarians https://pubmed.ncbi.nlm.nih.gov/12543... Distribution of blood glucose and prevalence of diabetes among centenarians and oldest-old in China: based on the China Hainan Centenarian Cohort Study and China Hainan Oldest-old Cohort Study https://pubmed.ncbi.nlm.nih.gov/32643... Prevalence and Ethnic Pattern of Diabetes and Prediabetes in China in 2013 https://pubmed.ncbi.nlm.nih.gov/28655... Families enriched for exceptional longevity also have increased health-span: findings from the long life family study https://pubmed.ncbi.nlm.nih.gov/24350... HOMA calculator: https://www.omnicalculator.com/health... Edited June 21, 2021 by Mike Lustgarten Quote Link to comment Share on other sites More sharing options...
Ron Put Posted June 21, 2021 Report Share Posted June 21, 2021 Thanks, Michael. But what if both insulin and glucose go up, yet HOMA is normal? Quote Link to comment Share on other sites More sharing options...
Todd Allen Posted June 22, 2021 Report Share Posted June 22, 2021 1 hour ago, Ron Put said: But what if both insulin and glucose go up, yet HOMA is normal? HOMA-IR is a calculated value based on fasted insulin and blood glucose. I think it is just multiplying them together with a constant. It is considered a mediocre estimate of insulin resistance used mainly because it is easy to do. Quote Link to comment Share on other sites More sharing options...
Mike Lustgarten Posted June 22, 2021 Author Report Share Posted June 22, 2021 Hey Ron, if glucose and insulin go up, even if they're normal, that's going in the wrong direction. It's the optimal range vs reference range debate... Quote Link to comment Share on other sites More sharing options...
mccoy Posted June 22, 2021 Report Share Posted June 22, 2021 (edited) 20 hours ago, Ron Put said: But what if both insulin and glucose go up, yet HOMA is normal? If both go up, then HOMA-IR should increase as well, the greater the HOMA-IR, the greater the insulin resistance, wrong direction as Mike says (and as Todd wrote, it's not a very reliable parameter). Edited June 22, 2021 by mccoy Quote Link to comment Share on other sites More sharing options...
Mike Lustgarten Posted June 22, 2021 Author Report Share Posted June 22, 2021 I disagree that it's not reliable-glucose and insulin are direct measures, it's practical to measure them while fasting, and accordingly, there should be minimal variability, and hence reliable if done fasted. Other measures of insulin sensitivity are usually done in the fed state (OGTT, ITT), but there may be more variability when eating real food especially considering that the OGTT involves drinking a bolus of sugar. Quote Link to comment Share on other sites More sharing options...
Saintor Posted July 1, 2021 Report Share Posted July 1, 2021 Impressive. I don''t understand how the KO mice were conditioned. In the video it says; "growth releasing hormone was knocked out" by the removal of a protein responsible for growth hormone. How was it done? What protein? I see a reference to "Nfe2l2 protein, mouse". Any equivalent for humans? Quote Link to comment Share on other sites More sharing options...
Mike Lustgarten Posted July 2, 2021 Author Report Share Posted July 2, 2021 Hey Saintor, here's the paper for how they knocked it out:https://pubmed.ncbi.nlm.nih.gov/15155578/ Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You can post now and register later. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.