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Can oxygen anosmia/hypoxia extend lifespan?


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I'll somehow combine this with the discussion on Hyperbaric medicine and HBOT ... but still gathering "facts". In the meantime ... some fat to chew on ....

The usual, under-researched, sensationalist, donation-seeking, super-duper-long-life DOT.ORG organizations -- with their picturesque web pages -- report this:



A study carried out by two researchers from the Chinese Academy of Science showed a possible link between hypoxia and longevity. They found out that elderly people living in hypoxia in the Tibetan Plateau tend to have a longer life than similarly aged people in other Chinese regions. In fact, the proportion of people older than 91 years old and centenarians keeps increasing in Tibet though the ratio of elderly people over 60 years old is still way lower than the rest of China.

The research findings were published in Cell Research on September 9, and their studies were based on China 2010 demographic census data. The researcher also noticed that there were many more males older than 100 years in this region than in the rest of the country.

....and ...


Hypoxia and gene expression

According to the researchers, Zhang Yaping and Wu Dongdong, the connection between a longer life expectancy and living in high altitude is not mere speculation. By stating that hypoxia (low-oxygen conditions) may promote longevity, the researchers suggest that this environment can alter the expression of aging-associated genes, resulting in the extension of lifespan.

Hypoxia and longevity: animal models

A genetic study on Drosophila melanogaster models showed that moderate hypoxia can extends their lifespan[1]. Another study also demonstrated that the lifespan of model animals such as such as Caenorhabditis elegans can be extended through hypoxia[2]. Finally, some wild mammals (naked mole-rats or whales) that spend most of their life in hypoxia seem to live longer[3].

However .... returning back to the safety of the search engine ... and looking at the SERP ... we find this:



In conclusion, our data suggest that worms can enjoy the beneficial effect of hypoxia signaling without actually being in hypoxia. By genetically manipulating the worm not to smell high O2, we can activate defence mechanisms that extend both healthspan and lifespan. Intriguingly, previous studies show that the smell of food can decrease the lifespan of worms and flies (when fed on a calorie-restricted diet) and a recent paper described how ablation of olfactory sensory neurons in mice makes them resistant to obesity caused by an enriched-fat diet [7].

Temporary exposure to high altitude results in lose-of-appetite and consequently weight loss in people (altitude anorexia). Although the molecular mechanism underlying altitude anorexia is not well understood, it appears that hypoxia is the causative agent that controls the change in appetite.

A fascinating direction for future studies will be to determine the interplay between oxygen sensing, appetite regulation and longevity.


It's that CR thang, again ... ain't it ?

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  • 1 year later...
On 5/25/2023 at 12:22 PM, BrianA said:

I'm ready to move to the high mountains 😀


Oxygen restriction helps fast-aging mice live longer, study reports


Me too - I wonder if there’s been any research on people living at different altitudes with substantially different oxygen concentrations and it’s possible impact on health span and lifespan.

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